Stability of collagen scaffold implants for animals with iatrogenic articular cartilage defoects

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dc.contributor.authorJančář, Josefcs
dc.contributor.authorVojtová, Lucycs
dc.contributor.authorNečas, Aloiscs
dc.contributor.authorSrnec, Robertcs
dc.contributor.authorUrbanová, Luciecs
dc.contributor.authorCrha, Michalcs
dc.coverage.issue4cs
dc.coverage.volume78cs
dc.date.accessioned2018-12-11T07:55:17Z
dc.date.available2018-12-11T07:55:17Z
dc.date.issued2009-12-15cs
dc.description.abstractSynthesis and characterization of biodegradable hydrogels based on collagen modified by addition of synthetic biodegradable copolymer intended for preparation of porous scaffolds for mesenchymal stem cells used for possible implantation to animals with articular surface defects was investigated. The synthetic biodegradable tri-block copolymer used was the block copolymer of polyethylene glycol (PEG), polylactic acid (PLA), polyglycolic acid (PGA) (PEG-PLGA) endcapped with itaconic acid (ITA). The water-soluble carbodiimide and N-hydroxysuccimide system (EDC-NHS) was chosen as the cross-linking agent used to control the rate of hydrogel resorption. Dependence of the physical properties of the prepared hydrogels on the concentration of the EDC-NHS cross-linker, reaction time and concentration of PEG-PLGA-ITA copolymer was examined. Swelling behaviour, thermal stability, surface morphology and degradation rate were also characterized. Based on the obtained results, it can be concluded that increase in concentration of the cross-linking agent, as well as prolonged cross-linking time and increased amount of synthetic copolymer lead to enhanced thermal stability of the gels together with a reduced swelling ratio and degradation rate in saline. The resorption rate of these gels used in preparation of cartilage scaffolds can be controlled over a wide time interval by varying the collagen/(PEG-PLGA-ITA) blend composition or the conditions of the cross-linking reaction.en
dc.description.abstractByla zkoumána příprava tkáňových substrátů na ázi kolagenu modifikovaného syntetickým PLA-PGA-PEG copolymerem a stabilita těchto substrátů v simulovaném tělním prostředí.cs
dc.formattextcs
dc.format.extent643-648cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACTA VETERINARIA BRNO. 2009, vol. 78, issue 4, p. 643-648.en
dc.identifier.doi10.2754/avb200978040643cs
dc.identifier.issn0001-7213cs
dc.identifier.other47810cs
dc.identifier.urihttp://hdl.handle.net/11012/137207
dc.language.isoencs
dc.publisherUniversity of Veterinary and Pharmaceutical Sciences in Brnocs
dc.relation.ispartofACTA VETERINARIA BRNOcs
dc.relation.urihttps://actavet.vfu.cz/78/4/0643/cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0001-7213/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectcollagenen
dc.subjectPEGen
dc.subjectPLAen
dc.subjectPGAen
dc.subjectEDCen
dc.subjectcross-linkingen
dc.subjectscaffolden
dc.subjectkolagen
dc.subjectPLA
dc.subjectPEG
dc.subjectPGA
dc.subjectEDC
dc.subjectsíťování
dc.subjecttkáňový substrát
dc.titleStability of collagen scaffold implants for animals with iatrogenic articular cartilage defoectsen
dc.title.alternativeStabilita kolagenních tkáňových substrátů pro zvířata s defekty chrupavekcs
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-47810en
sync.item.dbtypeVAVen
sync.item.insts2020.03.30 16:57:53en
sync.item.modts2020.03.30 15:51:46en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie materiálůcs
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