Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection

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dc.contributor.authorBohálová, Natáliacs
dc.contributor.authorCantara, Alessiocs
dc.contributor.authorBartas, Martincs
dc.contributor.authorKaura, Patrikcs
dc.contributor.authorŠťastný, Jiřícs
dc.contributor.authorPečinka, Petrcs
dc.contributor.authorFojta, Miroslavcs
dc.contributor.authorMergny, Jean-Louiscs
dc.contributor.authorBrázda, Václavcs
dc.coverage.issue1cs
dc.coverage.volume186cs
dc.date.accessioned2021-07-08T10:52:59Z
dc.date.available2021-07-08T10:52:59Z
dc.date.issued2021-07-01cs
dc.description.abstractG-quadruplexes contribute to the regulation of key molecular processes. Their utilization for antiviral therapy is an emerging field of contemporary research. Here we present comprehensive analyses of the presence and localization of putative G-quadruplex forming sequences (PQS) in all viral genomes currently available in the NCBI database (including subviral agents). The G4Hunter algorithm was applied to a pool of 11,000 accessible viral genomes representing 350 Mbp in total. PQS frequencies differ across evolutionary groups of viruses, and are enriched in repeats, replication origins, 5UTRs and 3UTRs. Importantly, PQS presence and localization is connected to viral lifecycles and corresponds to the type of viral infection rather than to nucleic acid type; while viruses routinely causing persistent infections in Metazoa hosts are enriched for PQS, viruses causing acute infections are significantly depleted for PQS. The unique localization of PQS identifies the importance of G-quadruplex-based regulation of viral replication and life cycle, providing a tool for potential therapeutic targeting.en
dc.formattextcs
dc.format.extent13-27cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationBIOCHIMIE. 2021, vol. 186, issue 1, p. 13-27.en
dc.identifier.doi10.1016/j.biochi.2021.03.017cs
dc.identifier.issn0300-9084cs
dc.identifier.other171738cs
dc.identifier.urihttp://hdl.handle.net/11012/200418
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofBIOCHIMIEcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0300908421000961cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0300-9084/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectAcute infectionen
dc.subjectBioinformaticsen
dc.subjectG-quadruplexen
dc.subjectG4Hunteren
dc.subjectPersistent infectionen
dc.subjectViral genomeen
dc.titleAnalyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infectionen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-171738en
sync.item.dbtypeVAVen
sync.item.insts2021.08.30 23:53:58en
sync.item.modts2021.08.30 22:49:40en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav automatizace a informatikycs
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