The use of fractionated Kraft lignin to improve the mechanical and biological properties of PVA-based scaffolds

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dc.contributor.authorRejmontová, Petracs
dc.contributor.authorKovalčík, Adriánacs
dc.contributor.authorHumpolíček, Petrcs
dc.contributor.authorCapáková, Zdenkacs
dc.contributor.authorWrzecionko, Erikcs
dc.contributor.authorSáha, Petrcs
dc.coverage.issue1cs
dc.coverage.volume9cs
dc.date.accessioned2020-08-05T10:58:04Z
dc.date.available2020-08-05T10:58:04Z
dc.date.issued2019-04-23cs
dc.description.abstractThe mechanical properties of poly(vinyl alcohol) (PVA)-based scaffolds were successfully improved. The improvements in mechanical properties correlated with the amount of Kraft lignin in PVA matrices. The critical property for any scaffold is its capacity to allow cells to ingrow and survive within its internal structure. The ingrowth of cells was tested using bioreactors creating simulated in vivo conditions. In the context of all the mentioned parameters, the most advantageous properties were exhibited by the scaffold containing 99 wt% PVA and 1 wt% Kraft lignin. The composites with 1 wt% Kraft lignin exhibited sufficient mechanical stability, a lack of cytotoxicity, and mainly the ability to allow the ingrowth of cells into the scaffold in a rotation bioreactor.en
dc.formattextcs
dc.format.extent12346-12353cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationRSC Advances. 2019, vol. 9, issue 1, p. 12346-12353.en
dc.identifier.doi10.1039/C8RA09757Gcs
dc.identifier.issn2046-2069cs
dc.identifier.other157312cs
dc.identifier.urihttp://hdl.handle.net/11012/194738
dc.language.isoencs
dc.publisherThe Royal Society of Chemistrycs
dc.relation.ispartofRSC Advancescs
dc.relation.urihttps://pubs.rsc.org/en/content/articlelanding/2019/ra/c8ra09757g#!divAbstractcs
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unportedcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2046-2069/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/cs
dc.subjectcytotoxicity; lignin; mechanical properties; poly(vinyl alcohol); scaffoldsen
dc.titleThe use of fractionated Kraft lignin to improve the mechanical and biological properties of PVA-based scaffoldsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionacceptedVersionen
sync.item.dbidVAV-157312en
sync.item.dbtypeVAVen
sync.item.insts2020.08.08 00:57:53en
sync.item.modts2020.08.08 00:15:10en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie potravin a biotechnologiícs
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