Now showing items 1-20 of 112

  • A 3D Microfluidic Chip for Electrochemical Detection of Hydrolysed Nucleic Bases by a Modified Glassy Carbon Electrode 

    Vlachová, Jana; Tmejová, Kateřina; Kopel, Pavel; Korabík, Michal; Zítka, Jan; Hynek, David; Kynický, Jindřich; Adam, Vojtěch; Kizek, René (MDPI AG, POSTFACH, CH-4005 BASEL, SWITZERLAND, 2015-02-01)
    Modification of carbon materials, especially graphene-based materials, has wide applications in electrochemical detection such as electrochemical lab-on-chip devices. A glassy carbon electrode (GCE) modified with chemically ...
  • An Acetylcholinesterase-Based Chronoamperometric Biosensor for Fast and Reliable Assay of Nerve Agents 

    Pohanka, Miroslav; Adam, Vojtěch; Kizek, René (MDPI, 2013-09-01)
    The enzyme acetylcholinesterase (AChE) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. It is sensitive to inhibition by organophosphate ...
  • Algal Biomass Analysis by Laser-Based Analytical Techniques - A Review 

    Pořízka, Pavel; Prochazková, Petra; Prochazka, David; Sládková, Lucia; Novotný, Jan; Petrilak, Michal; Brada, Michal; Samek, Ota; Pilát, Zdeněk; Zemánek, Pavel; Adam, Vojtěch; Kizek, René; Novotný, Karel; Kaiser, Jozef (MDPI AG, 2014-09-23)
    Algal biomass that is represented mainly by commercially grown algal strains has recently found many potential applications in various fields of interest. Its utilization has been found advantageous in the fields of ...
  • Amalgam electrode-based electrochemical detector for on-site direct determination of cadmium(II) and lead(II) from soils 

    Nejdl, Lukáš; Kynický, Jindřich; Brtnický, Martin; Vaculovičová, Markéta; Adam, Vojtěch (MDPI, 2017-08-01)
    Toxic metal contamination of the environment is a global issue. In this paper, we present a low-cost and rapid production of amalgam electrodes used for determination of Cd(II) and Pb(II) in environmental samples (soils ...
  • Amperometric Sensor for Detection of Chloride Ions 

    Trnková, Libuše; Adam, Vojtěch; Hubálek, Jaromír; Babula, Petr; Kizek, René (MDPI, 2008-09-15)
    Chloride ion sensing is important in many fields such as clinical diagnosis, environmental monitoring and industrial applications. We have measured chloride ions at a carbon paste electrode (CPE) and at a CPE modified with ...
  • Antibacterial activity of composite of graphene oxide with silver nanoparticles 

    Býtešníková, Zuzana; Koudelková, Zuzana; Richtera, Lukáš; Kopel, Pavel; Adam, Vojtěch (Mendel University in Brno, 2017-12-31)
    Looking for strategies against the development of antibiotic resistance is a major global object of interest for the public health. This work deals with synthesis of antimicrobial composites of graphene oxide (GO) with ...
  • Anticancerogenic effect of spices due to phenolic and flavonoid compounds – in vitro evaluation on prostate cells 

    Lacková, Zuzana; Buchtelová, Hana; Buchtová, Žaneta; Klejdus, Bořivoj; Heger, Zbyněk; Brtnický, Martin; Kynický, Jindřich; Zítka, Ondřej; Adam, Vojtěch (MDPI, 2017-09-28)
    This study shows the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines (PNT1A, 22RV1 and PC3). The results of an MTT assay on extracts from eight spices revealed the strongest inhibitory ...
  • Antimicrobial activity of CdTe QDs modified with lanthanides on pseudomonas aeruginosa 

    Jelínková, Pavlína; Koudelková, Zuzana; Kopel, Pavel; Moulick, Amitava; Adam, Vojtěch (Mendel University in Brno, 2017-12-31)
    The aim of this study is to obtain data based on an experimental procedure and check the effectiveness of some antibacterial agents against pathogenic bacteria. In the present experiment, two different nanoparticles (Cadmium ...
  • Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles 

    Urbánková, Lenka; Horký, Pavel; Skládanka, Jiří; Přibilová, Magdalena; Smolíková, Vendula; Nevrkla, Pavel; Cernei, Natalia Vladimirovna; Lacková, Zuzana; Hedbávný, Josef; Ridošková, Andrea; Adam, Vojtěch; Kopel, Pavel (PeerJ, 2018-05-28)
    Background: Selenium is an essential element; however, at higher doses, it can be toxic. Therefore, alternative nanotechnological solutions are required to overcome toxicological issues, rather than conventional alternatives. ...
  • Apoferritin as an ubiquitous nanocarrier with excellent shelf life 

    Dostálová, Simona; Vašíčková, Kateřina; Hynek, David; Křížková, Soňa; Richtera, Lukáš; Vaculovičová, Markéta; Eckschlager, Tomáš; Stiborová, Marie; Heger, Zbyněk; Adam, Vojtěch (Dove Media Press, 2017-03-24)
    Due to many adverse effects of conventional chemotherapy, novel methods of targeting drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for this specific delivery. Herein, we evaluated ...
  • Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery 

    Blažková, Iva; Nguyen, Hoai Viet; Dostálová, Simona; Kopel, Pavel; Stanisavljevic, Maja; Vaculovičová, Markéta; Stiborová, Marie; Eckschlager, Tomáš; Kizek, René; Adam, Vojtěch (MDPI, 2013-06-27)
    Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation ...
  • Apoferritin-mediated doxorubicin internalization through transferrin receptor 1 

    Krausová, Kateřina; Dostálová, Simona; Hynek, David; Křížková, Soňa; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2017-12-31)
    This work is aimed at the possibilities of targeted drug delivery into the tumour tissue. This approach can greatly reduce the otherwise serious side effects of conventional treatment - systemic toxicity. For this purpose, ...
  • The Application of Curve Fitting on the Voltammograms of Various Isoforms of Metallothioneins–Metal Complexes 

    Merlos Rodrigo, Miguel Ángel; Jimenez Jimenez, Ana Maria; Zítka, Ondřej; Richtera, Lukáš; Adam, Vojtěch (MDPI, 2017-03-01)
    The translation of metallothioneins (MTs) is one of the defense strategies by which organisms protect themselves from metal-induced toxicity. MTs belong to a family of proteins comprising MT-1, MT-2, MT-3, and MT-4 classes, ...
  • Are Early Somatic Embryos of the Norway Spruce (Picea abies (L.) Karst.) Organised? 

    Petřek, Jiří; Zítka, Ondřej; Adam, Vojtěch; Bartušek, Karel; Anjum, Naser A.; Pereira, Eduarda; Havel, Ladislav; Kizek, René (PLOS, 2015-12-01)
    Somatic embryogenesis in conifer species has great potential for the forestry industry. Hence, a number of methods have been developed for their efficient and rapid propagation through somatic embryogenesis. Although ...
  • Behaviour of zinc complexes and zinc sulphide nanoparticles revealed by using screen printed electrodes and spectrometry 

    Nejdl, Lukáš; Ruttkay-Nedecký, Branislav; Kudr, Jiří; Kremplová, Monika; Cernei, Natalia Vladimirovna; Prášek, Jan; Konečná, Marie; Hubálek, Jaromír; Zítka, Ondřej; Kynický, Jindřich; Kopel, Pavel; Kizek, René; Adam, Vojtěch (MDPI AQ, 2013-10-25)
    In this study, we focused on microfluidic electrochemical analysis of zinc complexes (Zn(phen)(his)Cl-2, Zn(his)Cl-2) and ZnS quantum dots (QDs) using printed electrodes. This method was chosen due to the simple (easy to ...
  • Bio-Sensing of Cadmium(II) Ions Using Staphylococcus aureus 

    Sochor, Jiří; Zítka, Ondřej; Hynek, David; Krejčová, Ludmila; Trnková, Libuše; Adam, Vojtěch; Hubálek, Jaromír; Kynický, Jindřich; Vrba, Radimír; Kizek, René (MDPI, 2011-11-08)
    Cadmium, as a hazardous pollutant commonly present in the living environment, represents an important risk to human health due to its undesirable effects (oxidative stress, changes in activities of many enzymes, interactions ...
  • Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes 

    Kopel, Pavel; Wawrzak, Dorota; Langer, Vratislav; Číhalová, Kristýna; Hegerová, Dagmar; Veselý, Radek; Adam, Vojtěch; Kizek, René (MDPI, 2015-06-01)
    1-(1H-Benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methanamine (abb) and 2-(1H-benzimidazol-2-ylmethylsulfanylmethyl)-1H-benzimidazole (tbb) have been prepared and characterized by elemental analysis. These bis(benzimidazoles) ...
  • Biosenzory na bázi modifikovaných TiO2 nanočástic 

    Valkovičová, Jiřina
    Práce je zaměřena na výrobu deponovaných kvantových teček z oxidu titaničitého za použití nanoporézní masky. Zabývá se zejména jejich luminiscenčními (fluorescenčními) vlastnostmi, díky kterým jsou vhodným základem biosenzoru ...
  • Carbon composite micro- and nano-tubes-based electrodes for detection of nucleic acids 

    Prášek, Jan; Húska, Dalibor; Trnková, Libuše; Adam, Vojtěch; Kizek, René; Hubálek, Jaromír (Springer, 2011-05-16)
    The first aim of this study was to fabricate vertically aligned multiwalled carbon nanotubes (MWCNTs). MWCNTs were successfully prepared by using plasma enhanced chemical vapour deposition. Further, three carbon composite ...
  • Characterization of upconversion nanoparticles by fluorescence spectrometry and capillary electrophoresis 

    Vaněčková, Tereza; Zítka, Jan; Hlaváček, Antonín; Adam, Vojtěch; Vaculovičová, Markéta (Mendel University in Brno, 2017-12-31)
    Upconversion nanoparticles (UCNPs) are a novel class of luminescent tags for applications in life and material sciences. Unlike traditional fluorophores, UCNPs exhibit emission of shorter wavelength under near-infrared ...