Now showing items 1-12 of 12

  • Anticancerogenic effect of spices due to phenolic and flavonoid compounds – in vitro evaluation on prostate cells 

    Lacková, Zuzana; Buchtelová, Hana; Buchtová, Žaneta; Klejdus, Bořivoj; Heger, Zbyněk; Brtnický, Martin; Kynický, Jindřich; Zítka, Ondřej; Adam, Vojtěch (MDPI, 2017-09-28)
    This study shows the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines (PNT1A, 22RV1 and PC3). The results of an MTT assay on extracts from eight spices revealed the strongest inhibitory ...
  • Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin 

    Merlos Rodrigo, Miguel Ángel; Dostálová, Simona; Buchtelová, Hana; Strmiska, Vladislav; Michálek, Petr; Křížková, Soňa; Vícha, Aleš; Eckschlager, Tomáš; Stiborová, Marie; Heger, Zbyněk; Adam, Vojtěch (Impact Journals, 2018-01-12)
    Human metallothionein-3 (hMT-3), also known as growth inhibitory factor, is predominantly expressed in the central nervous system. hMT-3 is presumed to participate in the processes of heavy metal detoxification, regulation ...
  • Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents 

    Buchtelová, Hana; Škubalová, Zuzana; Kudr, Jiří; Strmiska, Vladislav; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2019-01-02)
    The current study demonstrates design, preparation and characterization of biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) coated with three different polymers polyvinylpyrrolidone (PVP) polyoxyethylene ...
  • Effect of the selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells 

    Lacková, Zuzana; Buchtelová, Hana; Buchtová, Žaneta; Adam, Vojtěch; Zítka, Ondřej (Mendel University in Brno, 2017-12-31)
    In this study, the effect of selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells (PNT1A, 22RV1 and PC3) was observed. Synthetic standards of 3,4-dihydroxybenzaldehyde and naringenin ...
  • Evaluation of cytotoxicity of biphasic TiO2 nanoparticles with organic surface coatings 

    Škubalová, Zuzana; Buchtelová, Hana; Strmiska, Vladislav; Dostálová, Simona; Michálek, Petr; Křížková, Soňa; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2019-01-02)
    Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are used in topical ...
  • Improving cytocompatibility of CdTe quantum dots by Schiff-base-coordinated lanthanides surface doping 

    Buchtelová, Hana; Strmiska, Vladislav; Škubalová, Zuzana; Dostálová, Simona; Michálek, Petr; Křížková, Soňa; Hynek, David; Kalina, Lukáš; Richtera, Lukáš; Moulick, Amitava; Adam, Vojtěch; Heger, Zbyněk (BioMed Central, 2018-04-19)
    Background: Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable ...
  • Influence of liposomal platinum cytostatics on cancer cells by voltammetric methods 

    Sedláčková, Eliška; Laníková, Petra; Hynek, David; Krejčová, Ludmila; Buchtelová, Hana; Richtera, Lukáš; Adam, Vojtěch (TANGER, 2018-03-31)
    Aim of this work deals with closing of cisplatin into liposomes, the study of their stability and interaction with cancer cell lines. Commercial cisplatin cytostatic was encapsulated into three types of liposomes (L8, L10 ...
  • Investigating the interplay between sarcosine and Ca2+-dependent signaling in prostate cells 

    Strmiska, Vladislav; Buchtelová, Hana; Michálek, Petr; Křížková, Soňa; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2019-01-02)
    It has been shown that sarcosine supplementation stimulates proliferation and invassivenes of prostate cells. Nevertheless, the exact molecular mechanism responsible for this phenomenon is not known. In the present study ...
  • Novel Vancomycin-Peptide Conjugate as Potent Antibacterial Agent against Vancomycin-Resistant Staphylococcus aureus 

    Jelínková, Pavlína; Šplíchal, Zbyněk; Jimenez Jimenez, Ana Maria; Haddad, Yazan Abdulmajeed Eyadh; Mazumdar, Aninda; Sur, Vishma Pratap; Milosavljević, Vedran; Kopel, Pavel; Buchtelová, Hana; Guráň, Roman; Zítka, Ondřej; Richtera, Lukáš; Hegerová, Dagmar; Heger, Zbyněk; Moulick, Amitava; Adam, Vojtěch (Dove Press, 2018-11-01)
    Background: Increase in vancomycin (Van)-resistant bacterial strains including vancomycin-resistant Staphylococcus aureus (VRSA) and lack of new effective antibiotics have become a formidable health problem. Materials and ...
  • Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility 

    Buchtelová, Hana; Strmiska, Vladislav; Dostálová, Simona; Michálek, Petr; Křížková, Soňa; Kopel, Pavel; Hynek, David; Richtera, Lukáš; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2017-12-31)
    The current study demonstrates design preparation and characterization of biocompatible hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP) and polyoxyethylene stearate (POES). The ...
  • Sarcosine degradation pathway is involved in the epigenetics of prostate cells 

    Strmiska, Vladislav; Michálek, Petr; Buchtelová, Hana; Lacková, Zuzana; Guráň, Roman; Křížková, Soňa; Pompeiano Vaníčková, Lucie; Zítka, Ondřej; Stiborová, Marie; Eckschlager, Tomáš; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2017-12-31)
    It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine ...
  • Transcriptomic landscape of cisplatin-resistant neuroblastoma cells 

    Merlos Rodrigo, Miguel Ángel; Buchtelová, Hana; Jimenez Jimenez, Ana Maria; Adam, Pavlína; Babula, Petr; Heger, Zbyněk; Adam, Vojtěch (MDPI, 2019-03-31)
    The efficiency of cisplatin (CDDP) is significantly hindered by the development of resistance during the treatment course. To gain a detailed understanding of the molecular mechanisms underlying the development of cisplatin ...