Now showing items 1-20 of 39

  • Anticancerogenic effect of spices due to phenolic and flavonoid compounds – in vitro evaluation on prostate cells 

    Lacková, Zuzana; Buchtelová, Hana; Buchtová, Žaneta; Klejdus, Bořivoj; Heger, Zbyněk; Brtnický, Martin; Kynický, Jindřich; Zítka, Ondřej; Adam, Vojtěch (MDPI, 2017-09-28)
    This study shows the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines (PNT1A, 22RV1 and PC3). The results of an MTT assay on extracts from eight spices revealed the strongest inhibitory ...
  • Apoferritin as an ubiquitous nanocarrier with excellent shelf life 

    Dostálová, Simona; Vašíčková, Kateřina; Hynek, David; Křížková, Soňa; Richtera, Lukáš; Vaculovičová, Markéta; Eckschlager, Tomáš; Stiborová, Marie; Heger, Zbyněk; Adam, Vojtěch (Dove Media Press, 2017-03-24)
    Due to many adverse effects of conventional chemotherapy, novel methods of targeting drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for this specific delivery. Herein, we evaluated ...
  • Apoferritin-mediated doxorubicin internalization through transferrin receptor 1 

    Krausová, Kateřina; Dostálová, Simona; Hynek, David; Křížková, Soňa; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2017-12-31)
    This work is aimed at the possibilities of targeted drug delivery into the tumour tissue. This approach can greatly reduce the otherwise serious side effects of conventional treatment - systemic toxicity. For this purpose, ...
  • Biokompatibilní proteinové klece pro enkapsulaci a internalizaci malých interferujících RNA 

    Mokrý, Michal
    Práca sa zaoberá vytváraním apoferitínového nanotransportéru s enkapsulovanou fluorescenčne značenou malou interferujúcou RNA. Predmetom sú optimalizácia pH, množstva siRNA pri enkapsulácii siRNA do apoferitínu a ...
  • Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin 

    Merlos Rodrigo, Miguel Ángel; Dostálová, Simona; Buchtelová, Hana; Strmiska, Vladislav; Michálek, Petr; Křížková, Soňa; Vícha, Aleš; Eckschlager, Tomáš; Stiborová, Marie; Heger, Zbyněk; Adam, Vojtěch (Impact Journals, 2018-01-12)
    Human metallothionein-3 (hMT-3), also known as growth inhibitory factor, is predominantly expressed in the central nervous system. hMT-3 is presumed to participate in the processes of heavy metal detoxification, regulation ...
  • Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors 

    Dušková, Kateřina; Veselý, Štěpán; Do Carmo Silva, Joana Isabel; Cernei, Natalia Vladimirovna; Zítka, Ondřej; Heger, Zbyněk; Adam, Vojtěch; Havlová, Klára; Babjuk, Marek (The International Institute of Anticancer Research, 2018-04-01)
    Background: Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of ...
  • Effect of apoferritin surface-biomacromolecular modification on cellular uptake and inhibition of protein corona 

    Tesařová, Barbora; Dostálová, Simona; Charousová, Markéta; Škubalová, Zuzana; Guráň, Roman; Do, Tomáš; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2019-01-02)
    The effects of surface modifications (PEGylation and PASylation) of natural nanocarriers based on apoferritin (FRT) were tested in this work. The main goals of performed PEGylation/PASylation were decreased protein corona ...
  • Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents 

    Buchtelová, Hana; Škubalová, Zuzana; Kudr, Jiří; Strmiska, Vladislav; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2019-01-02)
    The current study demonstrates design, preparation and characterization of biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) coated with three different polymers polyvinylpyrrolidone (PVP) polyoxyethylene ...
  • Evaluation of cytotoxicity of biphasic TiO2 nanoparticles with organic surface coatings 

    Škubalová, Zuzana; Buchtelová, Hana; Strmiska, Vladislav; Dostálová, Simona; Michálek, Petr; Křížková, Soňa; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2019-01-02)
    Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are used in topical ...
  • Exposure to 17 beta-Oestradiol Induces Oxidative Stress in the Non-Oestrogen Receptor Invertebrate Species Eisenia fetida 

    Heger, Zbyněk; Michálek, Petr; Guráň, Roman; Havelková, Barbora; Komínková, Markéta; Cernei, Natalia Vladimirovna; Richtera, Lukáš; Beklová, Miroslava; Adam, Vojtěch; Kizek, René (PLOS, 2015-12-22)
    Background The environmental impacts of various substances on all levels of organisms are under investigation. Among these substances, endocrine-disrupting compounds (EDCs) present a threat, although the environmental ...
  • Flow Injection Analysis with Electrochemical Detection for Rapid Identification of Platinum-Based Cytostatics and Platinum Chlorides in Water 

    Komínková, Markéta; Heger, Zbyněk; Zítka, Ondřej; Kynický, Jindřich; Pohanka, Miroslav; Beklová, Miroslava; Adam, Vojtěch; Kizek, René (MDPI, 2014-02-04)
    Platinum-based cytostatics, such as cisplatin, carboplatin or oxaliplatin are widely used agents in the treatment of various types of tumors. Large amounts of these drugs are excreted through the urine of patients into ...
  • hNET as a target for neuroblastoma nanomedicine 

    Charousová, Markéta; Dostálová, Simona; Haddad, Yazan Abdulmajeed Eyadh; Strmiska, Vladislav; Křížková, Soňa; Hynek, David; Milosavljević, Vedran; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2017-12-31)
    Chemotherapy often results in various side effects, which can negatively affect health. Neuroblastoma, one of the most common types of childhood cancer, is but one of the examples, where side effects of chemotherapeutic ...
  • Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma 

    Pacík, Dalibor; Plevová, Mariana; Urbanová, Lucie; Lacková, Zuzana; Strmiska, Vladislav; Nečas, Alois; Heger, Zbyněk; Adam, Vojtěch (Springer Nature, 2018-12-01)
    The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. ...
  • Improving cytocompatibility of CdTe quantum dots by Schiff-base-coordinated lanthanides surface doping 

    Buchtelová, Hana; Strmiska, Vladislav; Škubalová, Zuzana; Dostálová, Simona; Michálek, Petr; Křížková, Soňa; Hynek, David; Kalina, Lukáš; Richtera, Lukáš; Moulick, Amitava; Adam, Vojtěch; Heger, Zbyněk (BioMed Central, 2018-04-19)
    Background: Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable ...
  • Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer 

    Heger, Zbyněk; Gumulec, Jaromír; Ondrák, Aleš; Škoda, Jan; Zítka, Zdeněk; Cernei, Natalia Vladimirovna; Masařík, Michal; Zítka, Ondřej; Adam, Vojtěch (MDPI, 2016-03-17)
    Herein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific ...
  • Investigating the interplay between sarcosine and Ca2+-dependent signaling in prostate cells 

    Strmiska, Vladislav; Buchtelová, Hana; Michálek, Petr; Křížková, Soňa; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2019-01-02)
    It has been shown that sarcosine supplementation stimulates proliferation and invassivenes of prostate cells. Nevertheless, the exact molecular mechanism responsible for this phenomenon is not known. In the present study ...
  • Magnetic nanoparticles: From Design and Synthesis to Real World Applications 

    Kudr, Jiří; Haddad, Yazan Abdulmajeed Eyadh; Richtera, Lukáš; Heger, Zbyněk; Černák, Mirko; Adam, Vojtěch; Zítka, Ondřej (MDPI, 2017-09-01)
    The increasing number of scientific publications focusing on magnetic materials indicates growing interest in the broader scientific community. Substantial progress was made in the synthesis of magnetic materials of desired ...
  • MALDI MSI of MeLiM melanoma: Searching for differences in protein profiles 

    Guráň, Roman; Pompeiano Vaníčková, Lucie; Horák, Vratislav; Křížková, Soňa; Michálek, Petr; Heger, Zbyněk; Zítka, Ondřej; Adam, Vojtěch (PLOS, 2017-12-08)
    Background Treatment of advanced cutaneous melanoma remains challenging, and new data on melanoma biology are required. The most widely accepted criteria for the prognostic evaluation of melanoma are histopathological and ...
  • Nanoparticles Suitable for BCAA Isolation Can Serve for Use in Magnetic Lipoplex-Based Delivery System for L, I, V, or R-rich Antimicrobial Peptides 

    Veselý, Radek; Jelínková, Pavlína; Hegerová, Dagmar; Cernei, Natalia Vladimirovna; Kopel, Pavel; Moulick, Amitava; Richtera, Lukáš; Heger, Zbyněk; Adam, Vojtěch; Zítka, Ondřej (MDPI, 2016-04-01)
    This paper investigates the synthesis of paramagnetic nanoparticles, which are able to bind branched chain amino acids (BCAAs)—leucine, valine, and isoleucine and, thus, serve as a tool for their isolation. Further, by ...
  • A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin 

    Heger, Zbyněk; Cernei, Natalia Vladimirovna; Kudr, Jiří; Gumulec, Jaromír; Blažková, Iva; Zítka, Ondřej; Eckschlager, Tomáš; Stiborová, Marie; Adam, Vojtěch; Kizek, René (MDPI, 2013-11-01)
    Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated ...