Now showing items 1-20 of 26

  • A 3D Microfluidic Chip for Electrochemical Detection of Hydrolysed Nucleic Bases by a Modified Glassy Carbon Electrode 

    Vlachová, Jana; Tmejová, Kateřina; Kopel, Pavel; Korabík, Michal; Zítka, Jan; Hynek, David; Kynický, Jindřich; Adam, Vojtěch; Kizek, René (MDPI AG, POSTFACH, CH-4005 BASEL, SWITZERLAND, 2015-02-01)
    Modification of carbon materials, especially graphene-based materials, has wide applications in electrochemical detection such as electrochemical lab-on-chip devices. A glassy carbon electrode (GCE) modified with chemically ...
  • Apoferritin as an ubiquitous nanocarrier with excellent shelf life 

    Dostálová, Simona; Vašíčková, Kateřina; Hynek, David; Křížková, Soňa; Richtera, Lukáš; Vaculovičová, Markéta; Eckschlager, Tomáš; Stiborová, Marie; Heger, Zbyněk; Adam, Vojtěch (Dove Media Press, 2017-03-24)
    Due to many adverse effects of conventional chemotherapy, novel methods of targeting drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for this specific delivery. Herein, we evaluated ...
  • Apoferritin-mediated doxorubicin internalization through transferrin receptor 1 

    Krausová, Kateřina; Dostálová, Simona; Hynek, David; Křížková, Soňa; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2017-12-31)
    This work is aimed at the possibilities of targeted drug delivery into the tumour tissue. This approach can greatly reduce the otherwise serious side effects of conventional treatment - systemic toxicity. For this purpose, ...
  • Bio-Sensing of Cadmium(II) Ions Using Staphylococcus aureus 

    Sochor, Jiří; Zítka, Ondřej; Hynek, David; Krejčová, Ludmila; Trnková, Libuše; Adam, Vojtěch; Hubálek, Jaromír; Kynický, Jindřich; Vrba, Radimír; Kizek, René (MDPI, 2011-11-08)
    Cadmium, as a hazardous pollutant commonly present in the living environment, represents an important risk to human health due to its undesirable effects (oxidative stress, changes in activities of many enzymes, interactions ...
  • The Composites of Graphene Oxide with Metal or Semimetal Nanoparticles and Their Effect on Pathogenic Microorganisms 

    Richtera, Lukáš; Hegerová, Dagmar; Číhalová, Kristýna; Kremplová, Monika; Milosavljević, Vedran; Kopel, Pavel; Blažková, Iva; Hynek, David; Adam, Vojtěch; Kizek, René (MDPI, 2015-06-01)
    The present experiment describes a synthesis process of composites based on graphene oxide, which was tested as a carrier for composites of metal- or metalloid-based nanoparticles (Cu, Zn, Mn, Ag, AgP, Se) and subsequently ...
  • Determination of Histamine in Silages Using Nanomaghemite Core (-Fe2O3)-Titanium Dioxide Shell Nanoparticles Off-Line Coupled with Ion Exchange Chromatography 

    Cernei, Natalia Vladimirovna; Lacková, Zuzana; Guráň, Roman; Hynek, David; Skládanka, Jiří; Horký, Pavel; Zítka, Ondřej; Adam, Vojtěch (MDPI, 2016-09-12)
    The presence of biogenic amines is a hallmark of degraded food and its products. Herein, we focused on the utilization of magnetic nanoparticles off-line coupled with ion exchange chromatography with post-column ninhydrin ...
  • Determination of Zinc, Cadmium, Lead, Copper and Silver Using a Carbon Paste Electrode and a Screen Printed Electrode Modified with Chromium(III) Oxide 

    Koudelková, Zuzana; Syrový, Tomáš; Ambrožová, Pavlína; Moravec, Zdeněk; Kubáč, Lubomír; Hynek, David; Richtera, Lukáš; Adam, Vojtěch (MDPI, 2017-08-01)
    In this study, the preparation and electrochemical application of a chromium(III) oxide modified carbon paste electrode (Cr-CPE) and a screen printed electrode (SPE), made from the same material and optimized for the simple, ...
  • Development of a magnetic electrochemical bar code array for point mutation detection in the H5N1 neuraminidase gene 

    Krejčová, Ludmila; Hynek, David; Kopel, Pavel; Merlos Rodrigo, Miguel Ángel; Adam, Vojtěch; Hubálek, Jaromír; Babula, Petr; Trnková, Libuše; Kizek, René (MDPI, 2013-07-15)
    Since its first official detection in the Guangdong province of China in 1996, the highly pathogenic avian influenza virus of H5N1 subtype (HPAI H5N1) has reportedly been the cause of outbreaks in birds in more than 60 ...
  • Effect of Ampicillin, Streptomycin, Penicillin and Tetracycline on Metal Resistant and Non-Resistant Staphylococcus aureus 

    Hegerová, Dagmar; Dostálová, Simona; Blažková, Iva; Michálek, Petr; Ruttkay-Nedecký, Branislav; Sklenář, Matěj; Nejdl, Lukáš; Kudr, Jiří; Gumulec, Jaromír; Tmejová, Kateřina; Konečná, Marie; Vaculovičová, Markéta; Hynek, David; Masařík, Michal; Kynický, Jindřich; Kizek, René; Adam, Vojtěch (MDPI AG, POSTFACH, 2014-03-19)
    There is an arising and concerning issue in the field of bacterial resistance, which is confirmed by the number of deaths associated with drug-resistant bacterial infections. The aim of this study was to compare the effects ...
  • Elektrochemické a matematické studium interakcí selenu s biologicky aktivními thioly 

    Slavík, Jan
    Proteiny s thiolovými skupinami interagují s ionty kovů v organismu. Udržují jejich homeostázu, účastní se buněčné signalizace, chrání buňku před účinky toxických kovů a detoxikují je. Tato práce je zaměřena na proteiny s ...
  • hNET as a target for neuroblastoma nanomedicine 

    Charousová, Markéta; Dostálová, Simona; Haddad, Yazan Abdulmajeed Eyadh; Strmiska, Vladislav; Křížková, Soňa; Hynek, David; Milosavljević, Vedran; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2017-12-31)
    Chemotherapy often results in various side effects, which can negatively affect health. Neuroblastoma, one of the most common types of childhood cancer, is but one of the examples, where side effects of chemotherapeutic ...
  • Improved Electrochemical Detection of Zinc Ions Using Electrode Modified with Electrochemically Reduced Graphene Oxide 

    Kudr, Jiří; Richtera, Lukáš; Nejdl, Lukáš; Xhaxhiu, Kledi; Vítek, Petr; Ruttkay-Nedecký, Branislav; Hynek, David; Kopel, Pavel; Adam, Vojtěch; Kizek, René (MDPI, 2016-01-01)
    Increasing urbanization and industrialization lead to the release of metals into the biosphere, which has become a serious issue for public health. In this paper, the direct electrochemical reduction of zinc ions is studied ...
  • Improving cytocompatibility of CdTe quantum dots by Schiff-base-coordinated lanthanides surface doping 

    Buchtelová, Hana; Strmiska, Vladislav; Škubalová, Zuzana; Dostálová, Simona; Michálek, Petr; Křížková, Soňa; Hynek, David; Kalina, Lukáš; Richtera, Lukáš; Moulick, Amitava; Adam, Vojtěch; Heger, Zbyněk (BioMed Central, 2018-04-19)
    Background: Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable ...
  • Influence of Magnetic Microparticles Isolation on Adenine Homonucleotides Structure 

    Kremplová, Monika; Fialová, Dana; Nejdl, Lukáš; Hynek, David; Trnková, Libuše; Hubálek, Jaromír; Kizek, René; Adam, Vojtěch (MDPI, 2014-03-01)
    The electroactivity of purine and pyrimidine bases is the most important property of nucleic acids that is very useful for determining oligonucleotides using square wave voltammetry. This study was focused on the electrochemical ...
  • Inovace přípravků pro výuku předmětu BDTS 

    Hynek, David
    Práce popisuje návrh vylepšení laboratorních úloh, které se budou používat v předmětu Diagnostika a testování elektronických systémů. Tento předmět se zabývá diagnostikou a testováním elektronických obvodů. Největší důraz ...
  • Interaction of Heavy Metal Ions with Carbon and Iron Based Particles 

    Fialová, Dana; Kremplová, Monika; Melichar, Lukáš; Kopel, Pavel; Hynek, David; Adam, Vojtěch; Kizek, René (MDPI, 2014-03-18)
    Due to the rapid development of industry and associated production of toxic waste, especially heavy metals, there is a great interest to create and upgrade new sorption materials to remove these pollutants from the ...
  • The Isolation of DNA by Polycharged Magnetic Particles: An Analysis of the Interaction by Zeta Potential and Particle Size 

    Haddad, Yazan Abdulmajeed Eyadh; Xhaxhiu, Kledi; Kopel, Pavel; Hynek, David; Zítka, Ondřej; Adam, Vojtěch (MDPI, 2016-04-20)
    Magnetic isolation of biological targets is in major demand in the biotechnology industry today. This study considers the interaction of four surface-modified magnetic micro- and nanoparticles with selected DNA fragments. ...
  • Modern Micro and Nanoparticle-Based Imaging Techniques 

    Vaculovičová, Markéta; Pekárková, Jana; Drbohlavová, Jana; Kopel, Pavel; Babula, Petr; Hynek, David; Adam, Vojtěch; Eckschlager, Tomáš; Hubálek, Jaromír; Stiborová, Marie; Kaiser, Jozef; Kizek, René (MDPI, 2012-11-02)
    The requirements for early diagnostics as well as effective treatment of insidious diseases such as cancer constantly increase the pressure on development of efficient and reliable methods for targeted drug/gene delivery ...
  • Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility 

    Buchtelová, Hana; Strmiska, Vladislav; Dostálová, Simona; Michálek, Petr; Křížková, Soňa; Kopel, Pavel; Hynek, David; Richtera, Lukáš; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2017-12-31)
    The current study demonstrates design preparation and characterization of biocompatible hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP) and polyoxyethylene stearate (POES). The ...
  • Serum metallothioneins in childhood tumours – A potential prognostic marker 

    Kruseová, Jarmila; Hynek, David; Adam, Vojtěch; Kizek, René; Průša, Richard; Hraběta, Jan; Eckschlager, Tomáš (MDPI, 2013-06-06)
    Metallothioneins (MT) are low molecular weight, cysteine-rich proteins maintaining metal ions homeostasis. They play a role in carcinogenesis and may also cause chemoresistance. The aim of the study was to explore the ...