Now showing items 1-16 of 16

  • Effect of Ampicillin, Streptomycin, Penicillin and Tetracycline on Metal Resistant and Non-Resistant Staphylococcus aureus 

    Hegerová, Dagmar; Dostálová, Simona; Blažková, Iva; Michálek, Petr; Ruttkay-Nedecký, Branislav; Sklenář, Matěj; Nejdl, Lukáš; Kudr, Jiří; Gumulec, Jaromír; Tmejová, Kateřina; Konečná, Marie; Vaculovičová, Markéta; Hynek, David; Masařík, Michal; Kynický, Jindřich; Kizek, René; Adam, Vojtěch (MDPI AG, POSTFACH, 2014-03-19)
    There is an arising and concerning issue in the field of bacterial resistance, which is confirmed by the number of deaths associated with drug-resistant bacterial infections. The aim of this study was to compare the effects ...
  • The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease 

    Roy, Sudeep; Gumulec, Jaromír; Kumar, Akhil; Raudenská, Martina; Baig, Mohd Hassan; Polanská, Hana; Balvan, Jan; Gupta, Mansi; Babula, Petr; Odstrčilík, Jan; Choi, Inho; Provazník, Ivo; Masařík, Michal (Wiley Periodicals, 2017-08-15)
    Metallothioneins (MTs) are a class of ubiquitously occurring low-molecular-weight cysteine- and metal-rich proteins containing sulfur-based metal clusters. MT-3 exhibits neuro-inhibitory activity. The possibility to enhance ...
  • Fluorescence Characterization of Gold Modified Liposomes with Antisense N-myc DNA Bound to the Magnetisable Particles with Encapsulated Anticancer Drugs (Doxorubicin, Ellipticine and Etoposide) 

    Skaličková, Sylvie; Nejdl, Lukáš; Kudr, Jiří; Ruttkay-Nedecký, Branislav; Jimenez Jimenez, Ana Maria; Kopel, Pavel; Kremplová, Monika; Masařík, Michal; Stiborová, Marie; Eckschlager, Tomáš; Adam, Vojtěch; Kizek, René (MDPI, 2016-03-01)
    Liposome-based drug delivery systems hold great potential for cancer therapy. The aim of this study was to design a nanodevice for targeted anchoring of liposomes (with and without cholesterol) with encapsulated anticancer ...
  • Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer 

    Heger, Zbyněk; Gumulec, Jaromír; Ondrák, Aleš; Škoda, Jan; Zítka, Zdeněk; Cernei, Natalia Vladimirovna; Masařík, Michal; Zítka, Ondřej; Adam, Vojtěch (MDPI, 2016-03-17)
    Herein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific ...
  • Metallothionein – Immunohistochemical Cancer Biomarker: A Meta-Analysis 

    Gumulec, Jaromír; Raudenská, Martina; Adam, Vojtěch; Kizek, René; Masařík, Michal (PLOS, 2014-01-08)
    Metallothionein (MT) has been extensively investigated as a molecular marker of various types of cancer. In spite of the fact that numerous reviews have been published in this field, no meta-analytical approach has been ...
  • Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating 

    Balvan, Jan; Gumulec, Jaromír; Raudenská, Martina; Křížová, Aneta; Štěpka, Petr; Babula, Petr; Kizek, René; Adam, Vojtěch; Masařík, Michal (PLOS, 2015-12-15)
    Resistant cancer phenotype is a key obstacle in the successful therapy of prostate cancer. The primary aim of our study was to explore resistance mechanisms in the advanced type of prostate cancer cells (PC-3) and to clarify ...
  • Paramagnetic Nanoparticles as a Platform for FRET-Based Sarcosine Picomolar Detection 

    Heger, Zbyněk; Cernei, Natalia Vladimirovna; Křížková, Soňa; Masařík, Michal; Kopel, Pavel; Hodek, Petr; Zítka, Ondřej; Adam, Vojtěch; Kizek, René (Nature Publishing Group, 2015-03-09)
    Herein, we describe an ultrasensitive specific biosensing system for detection of sarcosine as a potential biomarker of prostate carcinoma based on Forster resonance energy transfer (FRET). The FRET biosensor employs ...
  • Prostate tumor attenuation in the nu/nu murine model due to antisarcosine antibodies in folate targeted liposomes 

    Heger, Zbyněk; Polanská, Hana; Merlos Rodrigo, Miguel Ángel; Guráň, Roman; Kulich, Pavel; Kopel, Pavel; Masařík, Michal; Eckschlager, Tomáš; Stiborová, Marie; Kizek, René; Adam, Vojtěch (Nature Publishing Group, 2016-09-20)
    Herein, we describe the preparation of liposomes with folate-targeting properties for the encapsulation of anti-sarcosine antibodies (antisarAbs@LIP) and sarcosine (sar@LIP). The competitive inhibitory effects of exogenously ...
  • Prostate-Specific Membrane Antigen-Targeted Site-Directed Antibody-Conjugated Apoferritin Nanovehicle Favorably Influences In Vivo Side Effects of Doxorubicin 

    Dostálová, Simona; Polanská, Hana; Svobodová, Markéta; Balvan, Jan; Kryštofová, Olga; Haddad, Yazan Abdulmajeed Eyadh; Křížková, Soňa; Masařík, Michal; Eckschlager, Tomáš; Stiborová, Marie; Heger, Zbyněk; Adam, Vojtěch (Springer Nature, 2018-06-11)
    Herein, we describe the in vivo effects of doxorubicin (DOX) encapsulated in ubiquitous protein apoferritin (APO) and its efficiency and safety in anti-tumor treatment. APODOX is both passively (through Enhanced Permeability ...
  • The Role of Metallothionein in Oxidative Stress 

    Ruttkay-Nedecký, Branislav; Nejdl, Lukáš; Gumulec, Jaromír; Zítka, Ondřej; Masařík, Michal; Eckschlager, Tomáš; Stiborová, Marie; Adam, Vojtěch; Kizek, René (MDPI, 2013-03-15)
    Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in ...
  • Sarcosine as a potential prostate cancer biomarker – A review 

    Cernei, Natalia Vladimirovna; Heger, Zbyněk; Gumulec, Jaromír; Zítka, Ondřej; Masařík, Michal; Babula, Petr; Eckschlager, Tomáš; Stiborová, Marie; Kizek, René; Adam, Vojtěch (MDPI, 2013-07-04)
    Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that ...
  • Sarcosine up-regulates expression of genes involved in cell cycle progression of metastatic models of prostate cancer 

    Heger, Zbyněk; Merlos Rodrigo, Miguel Ángel; Michálek, Petr; Polanská, Hana; Masařík, Michal; Vít, Vítězslav; Plevová, Mariana; Pacík, Dalibor; Eckschlager, Tomáš; Stiborová, Marie; Adam, Vojtěch (PLOS, 2016-11-08)
    The effects of sarcosine on the processes driving prostate cancer (PCa) development remain still unclear. Herein, we show that a supplementation of metastatic PCa cells (androgen independent PC-3 and androgen dependent ...
  • Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis 

    Gumulec, Jaromír; Masařík, Michal; Adam, Vojtěch; Eckschlager, Tomáš; Provazník, Ivo; Kizek, René (PLOS, 2014-06-19)
    Background and Objectives: Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized ...
  • Sledování antioxidačních ukazatelů u dětí se zhoubnými nádory 

    Hořavová, Lenka
    Nádorová onemocnění patří mezi nejzávažnější zdravotní problémy dnešní doby. Hledání nových indikátorů pro rozpoznání počátku onemocnění je klíčovou úlohou dnešního výzkumu. Je známo, že oxidační stres souvisí s nerovnováhou ...
  • Spektrofotometrie přírodních látek – sekundárních metabolitů rostlin 

    Hořavová, Lenka
    Rostliny jsou významným zdrojem sekundárních metabolitů jako látek, které mají příznivý biologický vliv na zdravotní stav člověka a mají v současné moderní medicíně nezastupitelné místo. Mohou působit jak v prevenci, tak ...
  • Study of Interactions between Metallothionein and Cisplatin by using Differential Pulse Voltammetry Brdicka's reaction and Quartz Crystal Microbalance 

    Húska, Dalibor; Adam, Vojtěch; Masařík, Michal; Hubálek, Jaromír; Trnková, Libuše; Kizek, René (MDPI, 2009-03-15)
    Treatment strategies for tumour diseases are progressively focusing on personalization of medicine. However, this focus requires methods revealing the early general biological mechanisms, including the formation anti-cancer ...