Now showing items 1-8 of 8

  • Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation 

    Raudenská, Martina; Kratochvílová, Monika; Vičar, Tomáš; Gumulec, Jaromír; Balvan, Jan; Polanská, Hana; Přibyl, Jan; Masařík, Michal (NATURE PUBLISHING GROUP, 2019-02-07)
    We focused on the biomechanical and morphological characteristics of prostate cancer cells and their changes resulting from the effect of docetaxel, cisplatin, and long-term zinc supplementation. Cell population surviving ...
  • The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease 

    Roy, Sudeep; Gumulec, Jaromír; Kumar, Akhil; Raudenská, Martina; Baig, Mohd Hassan; Polanská, Hana; Balvan, Jan; Gupta, Mansi; Babula, Petr; Odstrčilík, Jan; Choi, Inho; Provazník, Ivo; Masařík, Michal (Wiley Periodicals, 2017-08-15)
    Metallothioneins (MTs) are a class of ubiquitously occurring low-molecular-weight cysteine- and metal-rich proteins containing sulfur-based metal clusters. MT-3 exhibits neuro-inhibitory activity. The possibility to enhance ...
  • LA-ICP-MS as a sensitive method for detection of nanoparticle-antibody conjugates in immunochemistry analysis 

    Vlčnovská, Marcela; Tvrdoňová, Michaela; Štossová, Aneta; Polanská, Hana; Vaculovičová, Markéta; Vaculovič, Tomáš; Masařík, Michal (Mendel University in Brno, 2019-12-31)
    Laser ablation followed by inductively coupled plasma mass spectrometry is an analytical method suitable for low concentration measurement of elements in a sample. This can be used not only for detection of elemental ...
  • Podnikatelský záměr rozvoje podniku 

    Audová, Petra
    Diplomová práce se zabývá nezbytnými kroky, které jsou nutné pro přípravu společnosti na vstup strategického partnera. Výstupem analytické části práce je SWOT analýza společnosti a jejího oborového okolí. Na základě ...
  • Prostate tumor attenuation in the nu/nu murine model due to antisarcosine antibodies in folate targeted liposomes 

    Heger, Zbyněk; Polanská, Hana; Merlos Rodrigo, Miguel Ángel; Guráň, Roman; Kulich, Pavel; Kopel, Pavel; Masařík, Michal; Eckschlager, Tomáš; Stiborová, Marie; Kizek, René; Adam, Vojtěch (Nature Publishing Group, 2016-09-20)
    Herein, we describe the preparation of liposomes with folate-targeting properties for the encapsulation of anti-sarcosine antibodies (antisarAbs@LIP) and sarcosine (sar@LIP). The competitive inhibitory effects of exogenously ...
  • Prostate-Specific Membrane Antigen-Targeted Site-Directed Antibody-Conjugated Apoferritin Nanovehicle Favorably Influences In Vivo Side Effects of Doxorubicin 

    Dostálová, Simona; Polanská, Hana; Svobodová, Markéta; Balvan, Jan; Kryštofová, Olga; Haddad, Yazan Abdulmajeed Eyadh; Křížková, Soňa; Masařík, Michal; Eckschlager, Tomáš; Stiborová, Marie; Heger, Zbyněk; Adam, Vojtěch (Springer Nature, 2018-06-11)
    Herein, we describe the in vivo effects of doxorubicin (DOX) encapsulated in ubiquitous protein apoferritin (APO) and its efficiency and safety in anti-tumor treatment. APODOX is both passively (through Enhanced Permeability ...
  • Sarcosine up-regulates expression of genes involved in cell cycle progression of metastatic models of prostate cancer 

    Heger, Zbyněk; Merlos Rodrigo, Miguel Ángel; Michálek, Petr; Polanská, Hana; Masařík, Michal; Vít, Vítězslav; Plevová, Mariana; Pacík, Dalibor; Eckschlager, Tomáš; Stiborová, Marie; Adam, Vojtěch (PLOS, 2016-11-08)
    The effects of sarcosine on the processes driving prostate cancer (PCa) development remain still unclear. Herein, we show that a supplementation of metastatic PCa cells (androgen independent PC-3 and androgen dependent ...
  • The Zinc-Schiff Base-Novicidin Complex as a Potential Prostate Cancer Therapy 

    Milosavljević, Vedran; Haddad, Yazan Abdulmajeed Eyadh; Merlos Rodrigo, Miguel Ángel; Moulick, Amitava; Polanská, Hana; Hynek, David; Heger, Zbyněk; Kopel, Pavel; Adam, Vojtěch (PLOS, 2016-10-11)
    Prostate cancer cells control energy metabolism by chelating intracellular zinc. Thus, zinc delivery has been a popular therapeutic approach for prostate cancer. Here, we propose the use of the membrane-penetrating peptide ...