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In Vivo Antibacterial Study of Zinc Phosphate-based Nanoparticles

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In Vivo Antibacterial Study of Zinc Phosphatebased Nanoparticles.pdf (1.790Mb)
Date
2019-02-01
Author
Kočiová, Silvia
Valečková, Vendula
Bytešníková, Zuzana
Horký, Pavel
Kopel, Pavel
Adam, Vojtěch
Šmerková, Kristýna
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Abstract
In animal nutrition, the nanotechnology is mostly used for the preparation of nanominerals, especially trace minerals, due to their low bioavailability. These nanominerals also showed advantageous effects at lower doses compared to conventional minerals. In addition, nanominerals can improve digestive efficacy, immunity and overall performance in livestock. In that case, we suggested and synthesized four types of zinc phosphatebased nanoparticles (ZnNPs), which achieved a significant antibacterial activity. After successful in vitro testing, we realized also in vivo study. We investigated the effect of zinc nanoparticles on rats after oral administration. Among others, the influence on total aerobic bacteria and coliforms in rat feces at day 10 or day 30 of treatment was monitored. In general, it has been observed a decrease of total aerobic and coliform bacteria population compared to untreated control group.
Keywords
Antibiotics, antimicrobial activity, zinc nanoparticles, nanominerals, rats
Persistent identifier
http://hdl.handle.net/11012/178356
Document type
Peer reviewed
Document version
Final PDF
Source
NANOCON 2018. 2019, p. 511-516.
https://nanocon2018.tanger.cz/cz/
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  • Chytré nanonástroje [296]
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