• čeština
    • English
    • русский
    • Deutsch
    • français
    • polski
    • українська
  • English 
    • čeština
    • English
    • русский
    • Deutsch
    • français
    • polski
    • українська
  • Login
View Item 
  •   Repository Home
  • Publikační činnost pracovníků VUT v Brně
  • Středoevropský technologický institut VUT
  • Chytré nanonástroje
  • View Item
  •   Repository Home
  • Publikační činnost pracovníků VUT v Brně
  • Středoevropský technologický institut VUT
  • Chytré nanonástroje
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Influence of liposomal platinum cytostatics on cancer cells by voltammetric methods

Thumbnail
View/Open
Influence of liposomal platinum cytostatics on cancer cells by voltammetric methods.pdf (1.489Mb)
Date
2018-03-31
Author
Sedláčková, Eliška
Laníková, Petra
Hynek, David
Krejčová, Ludmila
Buchtelová, Hana
Richtera, Lukáš
Adam, Vojtěch
Altmetrics
Metadata
Show full item record
Abstract
Aim of this work deals with closing of cisplatin into liposomes, the study of their stability and interaction with cancer cell lines. Commercial cisplatin cytostatic was encapsulated into three types of liposomes (L8, L10 and L15) of a different chemical composition. Each of liposomes had different ability to close cytostatic. L8 differs from L10 by containing cholesterol. In despite of L10 and L8, L15 liposome contains a synthetic 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (C41H78NO8P) – DOPE, which is generally found in cell membranes. The size of the liposomes was characterized by Dynamic Light Scattering (DLS). The amount of Pt-drug in liposomes was verified by electrochemical determination. Their stability was observed by differential pulse voltammetry (DPV). These studies also demonstrated, that the cisplatin is stable in physiological solution for at least 24 hours, which making it a suitable medium storage for this drug. Finally, the encapsulated cisplatin was applied to cancer cell lines and their viability was observed by MTT assay.
Keywords
Cisplatin, liposomes, electrochemistry, differential pulse voltammetry, cancer cell lines
Persistent identifier
http://hdl.handle.net/11012/178375
Document type
Peer reviewed
Document version
Final PDF
Source
NANOCON 2017. 2018, p. 548-553.
https://nanocon2017.tanger.cz/cz/
Collections
  • Chytré nanonástroje [296]
  • Ústav biomedicínského inženýrství [118]
  • oddělení-MEL-SIX [25]
Citace PRO

Portal of libraries | Central library on Facebook
DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback | Theme by @mire NV
 

 

Browse

All of repositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Statistics

View Usage Statistics

Portal of libraries | Central library on Facebook
DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback | Theme by @mire NV