Mouse model of congenital heart defects, dysmorphic facial features and intellectual developmental disorders as a result of nonfunctional CDK13
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Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFFID) syndrome in humans was recently associated with mutation in CDK13 gene. In order to assess the loss of function of Cdk13 during mouse development, we employed gene trap knock-out allele in Cdk13 gene. Embryonic lethality of Cdk13-deficient animals was observed by the embryonic day 16.5, live embryos were observed on E15.5. At this stage, improper development of multiple organs has been documented, partly resembling defects observed in patients with mutated CDK13. In particular, slower brain development, incomplete palate formation, kidney failure accompanied by congenital heart defects were detected. Based on further analyses, the lethality at this stage is a result of heart failure most likely due to multiple heart defects followed by insufficient blood circulation resulting in multiple organs dysfunctions. Thus, Cdk13 knock-out mice might be a very useful model for further studies focused on delineating signaling circuits and molecular mechanisms underlying CHDFFID caused by mutation in CDK13 gene.
Keywordscyclin-denpendent kinase, Transcription Regulation, development, cyclin-dependent kinase 13, Cyclin K
Document typePeer reviewed
Document versionFinal PDF
SourceFrontiers in Cell and Developmental Biology. 2019, vol. 7, issue 155, p. 1-19.