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  • Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells 

    Zemanová, Jana; Hylse, Ondřej; Čolláková, Jana; Veselý, Pavel; Oltová, Alexandra; Zápražná, Kristína; Kašpárková, Marie; Janovská, Pavlína; Verner, Jan; Kohoutek, Jiří; Dzimková, Marta; Bryja, Vítězslav; Jašková, Zuzana; Brychtová, Yvona; Paruch, Kamil; Trbušek, Martin (Impact Journals, 2016-08-19)
    Treatment options for TP53-mutated lymphoid tumors are very limited. In experimental models, TP53-mutated lymphomas were sensitive to direct inhibition of checkpoint kinase 1 (Chk1), a pivotal regulator of replication. We ...