Now showing items 1-7 of 7

  • Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection 

    Bohálová, Natália; Cantara, Alessio; Bartas, Martin; Kaura, Patrik; Šťastný, Jiří; Pečinka, Petr; Fojta, Miroslav; Mergny, Jean-Louis; Brázda, Václav (Elsevier, 2021-07-01)
    G-quadruplexes contribute to the regulation of key molecular processes. Their utilization for antiviral therapy is an emerging field of contemporary research. Here we present comprehensive analyses of the presence and ...
  • Formation of G-quadruplex and its utilizing for an automated spectrometric detection of cisplatin 

    Ruttkay-Nedecký, Branislav; Skaličková, Sylvie; Kremplová, Monika; Nejdl, Lukáš; Kudr, Jiří; Hynek, David; Novotná, Marie; Labuda, Jan; Adam, Vojtěch; Kizek, René (ESG, 2015-05-29)
    Here, we studied the formation of G-quadruplex using spectrophotometric methods (peroxidase activity of G-quadruplex) and verifications of obtained results by voltammetry (cytosine-adenine (CA) or guanine (G) peaks height). ...
  • G-Quadruplexes as Sensing Probes 

    Ruttkay-Nedecký, Branislav; Kudr, Jiří; Nejdl, Lukáš; Mašková, Darina; Kizek, René; Adam, Vojtěch (MDPI, 2013-12-01)
    Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. ...
  • G-quadruplexes in H1N1 influenza genomes 

    Brázda, Václav; Porubiaková, Otília; Cantara, Alessio; Bohálová, Natália; Coufal, Jan; Bartas, Martin; Fojta, Miroslav; Mergny, Jean-Louis (Springer Nature, 2021-01-24)
    Background: Influenza viruses are dangerous pathogens. Seventy-Seven genomes of recently emerged genotype 4 reassortant Eurasian avian-like H1N1 virus (G4-EA-H1N1) are currently available. We investigated the presence and ...
  • G4Killer web application: a tool to design G-quadruplex mutations 

    Brázda, Václav; Kolomazník, Jan; Mergny, Jean-Louis; Šťastný, Jiří (2020-05-15)
    G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. ...
  • In-depth Bioiformatic Analyses of Human SARS-CoV-2, SARS-CoV, MERS-CoV, and Other Nidovirales Suggest Important Roles of Noncanonical Nucleic Acid Structures in Their Lifecycles 

    Bartas, Martin; Brázda, Václav; Bohálová, Natália; Cantara, Alessio; Volná, Adriana; Stachurová, Tereza; Malachová, Katerina; Brázdová Jagelská, Eva; Porubiaková, Otília; Cerven, Jirí; Pečinka, Petr (Frontiers, 2020-04-03)
    Noncanonical nucleic acid structures play important roles in the regulation of molecular processess. Considering the importance of the ongoing coronavirus crisis, we decided to evaluate genomes of all coronaviruses sequences ...
  • Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences 

    Bohálová, Natália; Cantara, Alessio; Bartas, Martin; Kaura, Patrik; Šťastný, Jiří; Pečinka, Petr; Fojta, Miroslav; Brázda, Václav (MDPI, 2021-04-01)
    The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming ...