Browsing Publikační činnost pracovníků VUT v Brně by Subject "cabozantinib"
Now showing items 1-1 of 1
-
Identification of enzymes oxidizing the tyrosine kinase inhibitor cabozantinib: Cabozantinib is predominantly oxidized by CYP3A4 and its oxidation is stimulated by cyt b5 activity
(MDPI, 2020-12-30)Herein, the in vitro metabolism of tyrosine kinase inhibitor cabozantinib, the drug used for the treatment of metastatic medullary thyroid cancer and advanced renal cell carcinoma, was studied using hepatic microsomal ...