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Transcriptomic landscape of cisplatin-resistant neuroblastoma cells
(MDPI, 2019-03-31)
The efficiency of cisplatin (CDDP) is significantly hindered by the development of resistance during the treatment course. To gain a detailed understanding of the molecular mechanisms underlying the development of cisplatin ...
Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe-Dnmts axis
(FEBS Press, 2019-05-31)
DNA hypermethylation is one of the most common epigenetic modifications in prostate cancer (PCa). Several studies have delineated sarcosine as a PCa oncometabolite that increases the migration of malignant prostate cells ...
CdS quantum dots-based immunoassay combined with particle imprinted polymer technology and laser ablation ICP-MS as a versatile tool for protein detection
(Springer Nature, 2019-08-14)
For the first time, the combination of molecularly imprinted polymer (MIP) technology with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is presented with focus on an optimization of the LA-ICP-MS ...
In Vitro Interactions between 17 beta-Estradiol and DNA Result in Formation of the Hormone-DNA Complexes
(MDPI, 2014-08-01)
Beyond the role of 17 beta-estradiol (E-2) in reproduction and during the menstrual cycle, it has been shown to modulate numerous physiological processes such as cell proliferation, apoptosis, inflammation and ion transport ...
Lead Ions Encapsulated in Liposomes and Their Effect on Staphylococcus aureus
(MDPI, 2013-12-01)
The aim of the study was the preparation of a liposome complex with encapsulated lead ions, which were electrochemically detected. In particular, experiments were focused on the potential of using an electrochemical method ...
Algal Biomass Analysis by Laser-Based Analytical Techniques - A Review
(MDPI AG, 2014-09-23)
Algal biomass that is represented mainly by commercially grown algal strains has recently found many potential applications in various fields of interest. Its utilization has been found advantageous in the fields of ...
Specific Magnetic Isolation of E6 HPV16 Modified Magnetizable Particles Coupled with PCR and Electrochemical Detection
(MDPI, 2016-05-01)
The majority of carcinomas that were developed due to the infection with human
papillomavirus (HPV) are caused by high-risk HPV types, HPV16 and HPV18. These HPV types
contain the E6 and E7 oncogenes, so the fast detection ...
Sharka: The Past, The Present and The Future
(MDPI, 2012-11-01)
Members the Potyviridae family belong to a group of plant viruses that are causing devastating plant diseases with a significant impact on agronomy and economics. Plum pox virus (PPV), as a causative agent of sharka disease, ...
Nanocomposite furcellaran films - The influence of nanofillers on functional properties of furcellaran films and effect on linseed oil preservation
(MDPI, 2019-12-09)
Nanocomposite films that were based on furcellaran (FUR) and nanofillers (carbon quantum dots (CQDs), maghemite nanoparticles (MAN), and graphene oxide (GO)) were obtained by the casting method. The microstructure, as well ...
A simple electrochemical biosensor for the detection of methylated DNA and for methyltransferase activity monitoring
(Mendel University in Brno, 2019-12-31)
DNA methylation is one of the well-known epigenetic mechanism which plays a crucial role
in the development of various diseases, such as cancer, cardiovascular diseases or diabetes.
Electrochemical biosensors promise ...