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Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility
(Mendel University in Brno, 2017-12-31)
The current study demonstrates design preparation and characterization of biocompatible
hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP)
and polyoxyethylene stearate (POES). The ...
Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin
(Impact Journals, 2018-01-12)
Human metallothionein-3 (hMT-3), also known as growth inhibitory factor, is predominantly expressed in the central nervous system. hMT-3 is presumed to participate in the processes of heavy metal detoxification, regulation ...
Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration
(Springer Nature, 2017-01-10)
We describe a new procedure for the parallel mapping of selected metals in histologically characterized
tissue samples. Mapping is achieved via image registration of digital data obtained from two
neighbouring cryosections ...
Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors
(The International Institute of Anticancer Research, 2018-04-01)
Background: Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of ...
Trk receptors and neurotrophins cross-interactions: New perspective to manipulating therapeutic side-effects
(Frontiers, 2017-05-03)
Some therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons ...
Novel Vancomycin-Peptide Conjugate as Potent Antibacterial Agent against Vancomycin-Resistant Staphylococcus aureus
(Dove Press, 2018-11-01)
Background: Increase in vancomycin (Van)-resistant bacterial strains including vancomycin-resistant Staphylococcus aureus (VRSA) and lack of new effective antibiotics have become a formidable health problem.
Materials and ...
hNET as a target for neuroblastoma nanomedicine
(Mendel University in Brno, 2017-12-31)
Chemotherapy often results in various side effects, which can negatively affect health. Neuroblastoma, one of the most common types of childhood cancer, is but one of the examples, where side effects of chemotherapeutic ...
Sarcosine degradation pathway is involved in the epigenetics of prostate cells
(Mendel University in Brno, 2017-12-31)
It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine ...
Surface PEGylation and PASylation to regulate nanoparticle interactions with biological environment
(Mendel University in Brno, 2017-12-31)
Many researchers are developing nanocarriers in order to minimalize side effects of cytotoxic drugs during cancer treatment via chemotherapy. Nanocarriers can serve as a suitable platform for targeted drug delivery. To ...
Perspective of Use of Antiviral Peptides against Influenza Virus
(MDPI, 2015-10-01)
The threat of a worldwide influenza pandemic has greatly increased over the past
decade with the emergence of highly virulent avian influenza strains. The increased frequency
of drug-resistant influenza strains against ...