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Study of Linkage between Glutathione Pathway and the Antibiotic Resistance of Escherichia coli from Patients’ Swabs 

Komínková, Markéta; Kizek, René; Michálek, Petr; Číhalová, Kristýna; Guráň, Roman; Cernei, Natalia Vladimirovna; Nejdl, Lukáš; Šmerková, Kristýna; Dostálová, Simona; chudobova, Dagmar; Heger, Zbyněk; Veselý, Radek; Gumulec, Jaromír; Kynický, Jindřich; Xhaxhiu, Kledi; Zítka, Ondřej; Adam, Vojtěch (MDPI, 2015-05-31)
V této práci jsme se zaměřili na rozdíly mezi bakteriálních kultur E. coli, získaných ze stěrů infekčních ran pacientů ve srovnání s laboratorním E. coli. Navíc blokování proteinu odpovědné za syntézu glutathion ...
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Effect of apoferritin surface-biomacromolecular modification on cellular uptake and inhibition of protein corona 

Tesařová, Barbora; Dostálová, Simona; Charousová, Markéta; Škubalová, Zuzana; Guráň, Roman; Do, Tomáš; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2019-01-02)
The effects of surface modifications (PEGylation and PASylation) of natural nanocarriers based on apoferritin (FRT) were tested in this work. The main goals of performed PEGylation/PASylation were decreased protein corona ...
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Investigating the interplay between sarcosine and Ca2+-dependent signaling in prostate cells 

Strmiska, Vladislav; Buchtelová, Hana; Michálek, Petr; Křížková, Soňa; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2019-01-02)
It has been shown that sarcosine supplementation stimulates proliferation and invassivenes of prostate cells. Nevertheless, the exact molecular mechanism responsible for this phenomenon is not known. In the present study ...
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Evaluation of cytotoxicity of biphasic TiO2 nanoparticles with organic surface coatings 

Škubalová, Zuzana; Buchtelová, Hana; Strmiska, Vladislav; Dostálová, Simona; Michálek, Petr; Křížková, Soňa; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2019-01-02)
Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are used in topical ...
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Nanoparticles Suitable for BCAA Isolation Can Serve for Use in Magnetic Lipoplex-Based Delivery System for L, I, V, or R-rich Antimicrobial Peptides 

Veselý, Radek; Jelínková, Pavlína; Hegerová, Dagmar; Cernei, Natalia Vladimirovna; Kopel, Pavel; Moulick, Amitava; Richtera, Lukáš; Heger, Zbyněk; Adam, Vojtěch; Zítka, Ondřej (MDPI, 2016-04-01)
This paper investigates the synthesis of paramagnetic nanoparticles, which are able to bind branched chain amino acids (BCAAs)—leucine, valine, and isoleucine and, thus, serve as a tool for their isolation. Further, by ...
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Apoferritin as an ubiquitous nanocarrier with excellent shelf life 

Dostálová, Simona; Vašíčková, Kateřina; Hynek, David; Křížková, Soňa; Richtera, Lukáš; Vaculovičová, Markéta; Eckschlager, Tomáš; Stiborová, Marie; Heger, Zbyněk; Adam, Vojtěch (Dove Media Press, 2017-03-24)
Due to many adverse effects of conventional chemotherapy, novel methods of targeting drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for this specific delivery. Herein, we evaluated ...
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Prostate-Specific Membrane Antigen-Targeted Site-Directed Antibody-Conjugated Apoferritin Nanovehicle Favorably Influences In Vivo Side Effects of Doxorubicin 

Dostálová, Simona; Polanská, Hana; Svobodová, Markéta; Balvan, Jan; Kryštofová, Olga; Haddad, Yazan Abdulmajeed Eyadh; Křížková, Soňa; Masařík, Michal; Eckschlager, Tomáš; Stiborová, Marie; Heger, Zbyněk; Adam, Vojtěch (Springer Nature, 2018-06-11)
Herein, we describe the in vivo effects of doxorubicin (DOX) encapsulated in ubiquitous protein apoferritin (APO) and its efficiency and safety in anti-tumor treatment. APODOX is both passively (through Enhanced Permeability ...
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In Vitro Interactions between 17 beta-Estradiol and DNA Result in Formation of the Hormone-DNA Complexes 

Heger, Zbyněk; Guráň, Roman; Zítka, Ondřej; Beklová, Miroslava; Adam, Vojtěch; Kizek, René (MDPI, 2014-08-01)
Beyond the role of 17 beta-estradiol (E-2) in reproduction and during the menstrual cycle, it has been shown to modulate numerous physiological processes such as cell proliferation, apoptosis, inflammation and ion transport ...
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Targeting Neuroblastoma Cell Surface Proteins: Recommendations for Homology Modeling of hNET, ALK, and TrkB 

Haddad, Yazan Abdulmajeed Eyadh; Heger, Zbyněk; Adam, Vojtěch (Frontiers, 2017-01-20)
Targeted therapy is a promising approach for treatment of neuroblastoma as evident from the large number of targeting agents employed in clinical practice today. In the absence of known crystal structures, researchers rely ...
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Mass spectrometric imaging of cysteine rich proteins in human skin 

Pompeiano Vaníčková, Lucie; Guráň, Roman; Kollar, Sandor; Emri, Gabriela; Křížková, Soňa; Do, Tomáš; Heger, Zbyněk; Zítka, Ondřej; Adam, Vojtěch (Elsevier, 2019-03-15)
Looking insight pathological processes, metallothioneins (MTs) are considered to be potential biomarkers for monitoring of a development of various types of diseases, such as cancer. The early identification of the MTs in ...
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Heger, Zbyněk (64)
Adam, Vojtěch (59)Zítka, Ondřej (22)Křížková, Soňa (17)Eckschlager, Tomáš (15)Kizek, René (15)Michálek, Petr (15)Guráň, Roman (14)Haddad, Yazan Abdulmajeed Eyadh (14)Dostálová, Simona (13)... View MoreSubjectnanomedicine (7)neuroblastoma (7)prostate cancer (5)chemoresistance (4)cisplatin (4)sarcosine (4)Apoferritin (3)cancer (3)Escherichia coli (3)apoferritin (2)... View MoreDate Issued2022 (1)2021 (9)2020 (6)2019 (10)2018 (6)2017 (12)2016 (5)2015 (10)2014 (3)2013 (2)

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