Search
Now showing items 1-10 of 64
Study of Linkage between Glutathione Pathway and the Antibiotic Resistance of Escherichia coli from Patients’ Swabs
(MDPI, 2015-05-31)
V této práci jsme se zaměřili na rozdíly mezi bakteriálních kultur E. coli, získaných ze stěrů infekčních ran pacientů ve srovnání s laboratorním E. coli. Navíc blokování proteinu odpovědné za syntézu glutathion ...
Effect of apoferritin surface-biomacromolecular modification on cellular uptake and inhibition of protein corona
(Mendel University in Brno, 2019-01-02)
The effects of surface modifications (PEGylation and PASylation) of natural nanocarriers
based on apoferritin (FRT) were tested in this work. The main goals of performed
PEGylation/PASylation were decreased protein corona ...
Investigating the interplay between sarcosine and Ca2+-dependent signaling in prostate cells
(Mendel University in Brno, 2019-01-02)
It has been shown that sarcosine supplementation stimulates proliferation and invassivenes
of prostate cells. Nevertheless, the exact molecular mechanism responsible for this phenomenon is not
known. In the present study ...
Evaluation of cytotoxicity of biphasic TiO2 nanoparticles with organic surface coatings
(Mendel University in Brno, 2019-01-02)
Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of
their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are
used in topical ...
Nanoparticles Suitable for BCAA Isolation Can Serve for Use in Magnetic Lipoplex-Based Delivery System for L, I, V, or R-rich Antimicrobial Peptides
(MDPI, 2016-04-01)
This paper investigates the synthesis of paramagnetic nanoparticles, which are able to bind branched chain amino acids (BCAAs)—leucine, valine, and isoleucine and, thus, serve as a tool for their isolation. Further, by ...
Apoferritin as an ubiquitous nanocarrier with excellent shelf life
(Dove Media Press, 2017-03-24)
Due to many adverse effects of conventional chemotherapy, novel methods of targeting drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for this specific delivery. Herein, we evaluated ...
Prostate-Specific Membrane Antigen-Targeted Site-Directed Antibody-Conjugated Apoferritin Nanovehicle Favorably Influences In Vivo Side Effects of Doxorubicin
(Springer Nature, 2018-06-11)
Herein, we describe the in vivo effects of doxorubicin (DOX) encapsulated in ubiquitous protein apoferritin (APO) and its efficiency and safety in anti-tumor treatment. APODOX is both passively (through Enhanced Permeability ...
In Vitro Interactions between 17 beta-Estradiol and DNA Result in Formation of the Hormone-DNA Complexes
(MDPI, 2014-08-01)
Beyond the role of 17 beta-estradiol (E-2) in reproduction and during the menstrual cycle, it has been shown to modulate numerous physiological processes such as cell proliferation, apoptosis, inflammation and ion transport ...
Targeting Neuroblastoma Cell Surface Proteins: Recommendations for Homology Modeling of hNET, ALK, and TrkB
(Frontiers, 2017-01-20)
Targeted therapy is a promising approach for treatment of neuroblastoma as evident from the large number of targeting agents employed in clinical practice today. In the absence of known crystal structures, researchers rely ...
Mass spectrometric imaging of cysteine rich proteins in human skin
(Elsevier, 2019-03-15)
Looking insight pathological processes, metallothioneins (MTs) are considered to be potential biomarkers for monitoring of a development of various types of diseases, such as cancer. The early identification of the MTs in ...