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Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe-Dnmts axis
(FEBS Press, 2019-05-31)
DNA hypermethylation is one of the most common epigenetic modifications in prostate cancer (PCa). Several studies have delineated sarcosine as a PCa oncometabolite that increases the migration of malignant prostate cells ...
CdSe QD biosynthesis in yeast using tryptone-enriched media and their conjugation with a peptide hecate for bacterial detection and killing
(MDPI, 2019-10-31)
The physical and chemical synthesis methods of quantum dots (QDs) are generally unfavorable for biological applications. To overcome this limitation, the development of a novel "green" route to produce highly-fluorescent ...
In Vitro Interactions between 17 beta-Estradiol and DNA Result in Formation of the Hormone-DNA Complexes
(MDPI, 2014-08-01)
Beyond the role of 17 beta-estradiol (E-2) in reproduction and during the menstrual cycle, it has been shown to modulate numerous physiological processes such as cell proliferation, apoptosis, inflammation and ion transport ...
Lead Ions Encapsulated in Liposomes and Their Effect on Staphylococcus aureus
(MDPI, 2013-12-01)
The aim of the study was the preparation of a liposome complex with encapsulated lead ions, which were electrochemically detected. In particular, experiments were focused on the potential of using an electrochemical method ...
Sarcosine as a potential prostate cancer biomarker – A review
(MDPI, 2013-07-04)
Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that ...
Paramagnetic Nanoparticles as a Platform for FRET-Based Sarcosine Picomolar Detection
(Nature Publishing Group, 2015-03-09)
Herein, we describe an ultrasensitive specific biosensing system for detection of sarcosine as a potential
biomarker of prostate carcinoma based on Forster resonance energy transfer (FRET). The FRET biosensor
employs ...
Flow Injection Analysis with Electrochemical Detection for Rapid Identification of Platinum-Based Cytostatics and Platinum Chlorides in Water
(MDPI, 2014-02-04)
Platinum-based cytostatics, such as cisplatin, carboplatin or oxaliplatin are widely used agents in the treatment of various types of tumors. Large amounts of these
drugs are excreted through the urine of patients into ...
Determination of hydroxyproline using ion-exchange liquid chromatography with vis detector and high performance liquid chromatography with fluorescence detector
(Mendel University in Brno, 2017-12-31)
The first aim of the experiment was an optimization of the method for determination of hydroxyproline in a pig skin using high-performance liquid chromatography with fluorescence detector (HPLC-FLD) and ion-exchange liquid ...
Sarcosine degradation pathway is involved in the epigenetics of prostate cells
(Mendel University in Brno, 2017-12-31)
It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine ...
Bio-Sensing of Cadmium(II) Ions Using Staphylococcus aureus
(MDPI, 2011-11-08)
Cadmium, as a hazardous pollutant commonly present in the living environment, represents an important risk to human health due to its undesirable effects (oxidative stress, changes in activities of many enzymes, interactions ...