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Sarcosine degradation pathway is involved in the epigenetics of prostate cells
(Mendel University in Brno, 2017-12-31)
It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine ...
Improving cytocompatibility of CdTe quantum dots by Schiff-base-coordinated lanthanides surface doping
(BioMed Central, 2018-04-19)
Background: Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable ...
Novel Vancomycin-Peptide Conjugate as Potent Antibacterial Agent against Vancomycin-Resistant Staphylococcus aureus
(Dove Press, 2018-11-01)
Background: Increase in vancomycin (Van)-resistant bacterial strains including vancomycin-resistant Staphylococcus aureus (VRSA) and lack of new effective antibiotics have become a formidable health problem.
Materials and ...
Transcriptomic landscape of cisplatin-resistant neuroblastoma cells
(MDPI, 2019-03-31)
The efficiency of cisplatin (CDDP) is significantly hindered by the development of resistance during the treatment course. To gain a detailed understanding of the molecular mechanisms underlying the development of cisplatin ...
Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents
(Mendel University in Brno, 2019-01-02)
The current study demonstrates design, preparation and characterization of biocompatible
superparamagnetic iron oxide nanoparticles (SPIONs) coated with three different polymers
polyvinylpyrrolidone (PVP) polyoxyethylene ...
Evaluation of cytotoxicity of biphasic TiO2 nanoparticles with organic surface coatings
(Mendel University in Brno, 2019-01-02)
Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of
their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are
used in topical ...
Investigating the interplay between sarcosine and Ca2+-dependent signaling in prostate cells
(Mendel University in Brno, 2019-01-02)
It has been shown that sarcosine supplementation stimulates proliferation and invassivenes
of prostate cells. Nevertheless, the exact molecular mechanism responsible for this phenomenon is not
known. In the present study ...
Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility
(Mendel University in Brno, 2017-12-31)
The current study demonstrates design preparation and characterization of biocompatible
hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP)
and polyoxyethylene stearate (POES). The ...
Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin
(Impact Journals, 2018-01-12)
Human metallothionein-3 (hMT-3), also known as growth inhibitory factor, is predominantly expressed in the central nervous system. hMT-3 is presumed to participate in the processes of heavy metal detoxification, regulation ...
Anticancerogenic effect of spices due to phenolic and flavonoid compounds – in vitro evaluation on prostate cells
(MDPI, 2017-09-28)
This study shows the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines (PNT1A, 22RV1 and PC3). The results of an MTT assay on extracts from eight spices revealed the strongest inhibitory ...