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Sarcosine degradation pathway is involved in the epigenetics of prostate cells
(Mendel University in Brno, 2017-12-31)
It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine ...
Improving cytocompatibility of CdTe quantum dots by Schiff-base-coordinated lanthanides surface doping
(BioMed Central, 2018-04-19)
Background: Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable ...
Sarcosine up-regulates expression of genes involved in cell cycle progression of metastatic models of prostate cancer
(PLOS, 2016-11-08)
The effects of sarcosine on the processes driving prostate cancer (PCa) development remain still unclear. Herein, we show that a supplementation of metastatic PCa cells (androgen independent PC-3 and androgen dependent ...
Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin
(Impact Journals, 2018-01-12)
Human metallothionein-3 (hMT-3), also known as growth inhibitory factor, is predominantly expressed in the central nervous system. hMT-3 is presumed to participate in the processes of heavy metal detoxification, regulation ...
Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility
(Mendel University in Brno, 2017-12-31)
The current study demonstrates design preparation and characterization of biocompatible
hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP)
and polyoxyethylene stearate (POES). The ...
MALDI MSI of MeLiM melanoma: Searching for differences in protein profiles
(PLOS, 2017-12-08)
Background
Treatment of advanced cutaneous melanoma remains challenging, and new data on melanoma biology are required. The most widely accepted criteria for the prognostic evaluation of melanoma are histopathological and ...
Investigating the interplay between sarcosine and Ca2+-dependent signaling in prostate cells
(Mendel University in Brno, 2019-01-02)
It has been shown that sarcosine supplementation stimulates proliferation and invassivenes
of prostate cells. Nevertheless, the exact molecular mechanism responsible for this phenomenon is not
known. In the present study ...
Evaluation of cytotoxicity of biphasic TiO2 nanoparticles with organic surface coatings
(Mendel University in Brno, 2019-01-02)
Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of
their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are
used in topical ...
Study of Linkage between Glutathione Pathway and the Antibiotic Resistance of Escherichia coli from Patients’ Swabs
(MDPI, 2015-05-31)
In this work, we focused on the differences between bacterial cultures of E. coli obtained from swabs of infectious wounds of patients compared to laboratory E. coli. In addition, blocking of the protein responsible for ...
Exposure to 17 beta-Oestradiol Induces Oxidative Stress in the Non-Oestrogen Receptor Invertebrate Species Eisenia fetida
(PLOS, 2015-12-22)
Background
The environmental impacts of various substances on all levels of organisms are under investigation. Among these substances, endocrine-disrupting compounds (EDCs) present a threat, although the environmental ...