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Study of Linkage between Glutathione Pathway and the Antibiotic Resistance of Escherichia coli from Patients’ Swabs
(MDPI, 2015-05-31)
V této práci jsme se zaměřili na rozdíly mezi bakteriálních kultur E. coli, získaných ze stěrů infekčních ran pacientů ve srovnání s laboratorním E. coli. Navíc blokování proteinu odpovědné za syntézu glutathion ...
Sarcosine degradation pathway is involved in the epigenetics of prostate cells
(Mendel University in Brno, 2017-12-31)
It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine ...
Sarcosine up-regulates expression of genes involved in cell cycle progression of metastatic models of prostate cancer
(PLOS, 2016-11-08)
The effects of sarcosine on the processes driving prostate cancer (PCa) development remain still unclear. Herein, we show that a supplementation of metastatic PCa cells (androgen independent PC-3 and androgen dependent ...
Improving cytocompatibility of CdTe quantum dots by Schiff-base-coordinated lanthanides surface doping
(BioMed Central, 2018-04-19)
Background: Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable ...
MALDI MSI of MeLiM melanoma: Searching for differences in protein profiles
(PLOS, 2017-12-08)
Background
Treatment of advanced cutaneous melanoma remains challenging, and new data on melanoma biology are required. The most widely accepted criteria for the prognostic evaluation of melanoma are histopathological and ...
Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe-Dnmts axis
(FEBS Press, 2019-05-31)
DNA hypermethylation is one of the most common epigenetic modifications in prostate cancer (PCa). Several studies have delineated sarcosine as a PCa oncometabolite that increases the migration of malignant prostate cells ...
Evaluation of cytotoxicity of biphasic TiO2 nanoparticles with organic surface coatings
(Mendel University in Brno, 2019-01-02)
Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of
their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are
used in topical ...
Investigating the interplay between sarcosine and Ca2+-dependent signaling in prostate cells
(Mendel University in Brno, 2019-01-02)
It has been shown that sarcosine supplementation stimulates proliferation and invassivenes
of prostate cells. Nevertheless, the exact molecular mechanism responsible for this phenomenon is not
known. In the present study ...
Study of Linkage between Glutathione Pathway and the Antibiotic Resistance of Escherichia coli from Patients Swab
(MDPI, 2015-03-31)
In this work, we focused on the differences between bacterial cultures of E. coli
obtained from swabs of infectious wounds of patients compared to laboratory E. coli. In addition,
blocking of the protein responsible for ...
Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility
(Mendel University in Brno, 2017-12-31)
The current study demonstrates design preparation and characterization of biocompatible
hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP)
and polyoxyethylene stearate (POES). The ...