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hNET as a target for neuroblastoma nanomedicine
(Mendel University in Brno, 2017-12-31)
Chemotherapy often results in various side effects, which can negatively affect health. Neuroblastoma, one of the most common types of childhood cancer, is but one of the examples, where side effects of chemotherapeutic ...
Surface PEGylation and PASylation to regulate nanoparticle interactions with biological environment
(Mendel University in Brno, 2017-12-31)
Many researchers are developing nanocarriers in order to minimalize side effects of cytotoxic drugs during cancer treatment via chemotherapy. Nanocarriers can serve as a suitable platform for targeted drug delivery. To ...
Sarcosine degradation pathway is involved in the epigenetics of prostate cells
(Mendel University in Brno, 2017-12-31)
It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine ...
Apoferritin as an ubiquitous nanocarrier with excellent shelf life
(Dove Media Press, 2017-03-24)
Due to many adverse effects of conventional chemotherapy, novel methods of targeting drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for this specific delivery. Herein, we evaluated ...
Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration
(Springer Nature, 2017-01-10)
We describe a new procedure for the parallel mapping of selected metals in histologically characterized
tissue samples. Mapping is achieved via image registration of digital data obtained from two
neighbouring cryosections ...
Trk receptors and neurotrophins cross-interactions: New perspective to manipulating therapeutic side-effects
(Frontiers, 2017-05-03)
Some therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons ...
Magnetic nanoparticles: From Design and Synthesis to Real World Applications
(MDPI, 2017-09-01)
The increasing number of scientific publications focusing on magnetic materials indicates growing interest in the broader scientific community. Substantial progress was made in the synthesis of magnetic materials of desired ...
Anticancerogenic effect of spices due to phenolic and flavonoid compounds – in vitro evaluation on prostate cells
(MDPI, 2017-09-28)
This study shows the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines (PNT1A, 22RV1 and PC3). The results of an MTT assay on extracts from eight spices revealed the strongest inhibitory ...
Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility
(Mendel University in Brno, 2017-12-31)
The current study demonstrates design preparation and characterization of biocompatible
hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP)
and polyoxyethylene stearate (POES). The ...
Apoferritin-mediated doxorubicin internalization through transferrin receptor 1
(Mendel University in Brno, 2017-12-31)
This work is aimed at the possibilities of targeted drug delivery into the tumour tissue. This approach can greatly reduce the otherwise serious side effects of conventional treatment - systemic toxicity. For this purpose, ...