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Transcriptomic landscape of cisplatin-resistant neuroblastoma cells
(MDPI, 2019-03-31)
The efficiency of cisplatin (CDDP) is significantly hindered by the development of resistance during the treatment course. To gain a detailed understanding of the molecular mechanisms underlying the development of cisplatin ...
Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe-Dnmts axis
(FEBS Press, 2019-05-31)
DNA hypermethylation is one of the most common epigenetic modifications in prostate cancer (PCa). Several studies have delineated sarcosine as a PCa oncometabolite that increases the migration of malignant prostate cells ...
Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents
(Mendel University in Brno, 2019-01-02)
The current study demonstrates design, preparation and characterization of biocompatible
superparamagnetic iron oxide nanoparticles (SPIONs) coated with three different polymers
polyvinylpyrrolidone (PVP) polyoxyethylene ...
Evaluation of cytotoxicity of biphasic TiO2 nanoparticles with organic surface coatings
(Mendel University in Brno, 2019-01-02)
Titanium dioxide nanoparticles (TiO2 NPs) are used in lots of human applications because of
their extraordinary nano scaled properties. Particularly, due to their photoprotective properties, they are
used in topical ...
Effect of apoferritin surface-biomacromolecular modification on cellular uptake and inhibition of protein corona
(Mendel University in Brno, 2019-01-02)
The effects of surface modifications (PEGylation and PASylation) of natural nanocarriers
based on apoferritin (FRT) were tested in this work. The main goals of performed
PEGylation/PASylation were decreased protein corona ...
Investigating the interplay between sarcosine and Ca2+-dependent signaling in prostate cells
(Mendel University in Brno, 2019-01-02)
It has been shown that sarcosine supplementation stimulates proliferation and invassivenes
of prostate cells. Nevertheless, the exact molecular mechanism responsible for this phenomenon is not
known. In the present study ...
Tuning the surface coating of IONs toward efficient sonochemical tethering and sustained liberation of topoisomerase II poisons
(Dove Medical Press, 2019-09-17)
Background: Iron oxide nanoparticles (IONs) have been increasingly utilized in a wide spectrum of biomedical applications. Surface coatings of IONs can bestow a number of exceptional properties, including enhanced stability ...
Mass spectrometric imaging of cysteine rich proteins in human skin
(Elsevier, 2019-03-15)
Looking insight pathological processes, metallothioneins (MTs) are considered to be potential biomarkers for monitoring of a development of various types of diseases, such as cancer. The early identification of the MTs in ...
Rotamer Dynamics: Analysis of Rotamers in Molecular Dynamics Simulations of Proteins
(Elsevier, 2019-06-04)
Given by chi torsional angles, rotamers describe the side-chain conformations of amino acid residues in a protein based on the rotational isomers (hence the word rotamer). Constructed rotamer libraries, based on either ...
Proteomic signature of neuroblastoma cells UKF-NB-4 reveals key role of lysosomal sequestration and the proteasome complex in acquiring chemoresistance to cisplatin
(American Chemical Society, 2019-03-25)
Cisplatin (CDDP) is a widely used agent in the treatment of neuroblastoma. Unfortunately, the development of acquired chemoresistance limits its clinical use. To gain a detailed understanding of the mechanisms underlying ...