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Ten quick tips for homology modeling of high-resolution protein 3D structures 

Haddad, Yazan Abdulmajeed Eyadh; Adam, Vojtěch; Heger, Zbyněk (PLOS, 2020-04-30)
The purpose of this quick guide is to help new modelers who have little or no background in comparative modeling yet are keen to produce high-resolution protein 3D structures for their study by following systematic good ...
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Drug Sequestration in Lysosomes as One of the Mechanisms of Chemoresistance of Cancer Cells and the Possibilities of Its Inhibition 

Hraběta, Jan; Belhajová, Marie; Šubrtová, Hana; Merlos Rodrigo, Miguel Ángel; Heger, Zbyněk; Eckschlager, Tomáš (MDPI, 2020-06-30)
Resistance to chemotherapeutics and targeted drugs is one of the main problems in successful cancer therapy. Various mechanisms have been identified to contribute to drug resistance. One of those mechanisms is lysosome-mediated ...
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Metallothionein Isoforms as Double Agents - Their Roles in Carcinogenesis, Cancer Progression and Chemoresistance 

Merlos Rodrigo, Miguel Ángel; Jimenez Jimenez, Ana Maria; Haddad, Yazan Abdulmajeed Eyadh; Adam, Pavlína; Křížková, Soňa; Heger, Zbyněk; Adam, Vojtěch (Elsevier, 2020-09-30)
Metallothioneins (MTs) are small cysteine-rich intracellular proteins with four major isoforms identified in mammals, designated MT-1 through MT-4. The best known biological functions of MTs are their ability to bind and ...
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Norepinephrine Transporter-Derived Homing Peptides Enable Rapid Endocytosis of Drug Delivery Nanovehicles into Neuroblastoma Cells 

Haddad, Yazan Abdulmajeed Eyadh; Charousová, Markéta; Životská, Hana; Šplíchal, Zbyněk; Merlos Rodrigo, Miguel Ángel; Michálková, Hana; Křížková, Soňa; Tesařová, Barbora; Richtera, Lukáš; Vítek, Petr; Stokowa-Soltys, Kamila; Hynek, David; Milosavljević, Vedran; Rex, Simona; Heger, Zbyněk (BioMed Central, 2020-07-13)
Background: Currently, the diagnosis and treatment of neuroblastomas-the most frequent solid tumors in children-exploit the norepinephrine transporter (hNET) via radiolabeled norepinephrine analogs. We aim to develop a ...
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Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels 

Pekařík, Vladimír; Pešková, Marie; Duben, Jakub; Remeš, Marek; Heger, Zbyněk (Springer Nature, 2020-07-23)
Allyl- and propargyl ethers of umbelliferone are sensitive probes for palladium and platinum, including anticancer compounds cisplatin, carboplatin and oxaliplatin, and effective for direct visualization of protein and DNA ...

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Heger, Zbyněk (5)
Haddad, Yazan Abdulmajeed Eyadh (3)Merlos Rodrigo, Miguel Ángel (3)Adam, Vojtěch (2)Křížková, Soňa (2)Adam, Pavlína (1)Belhajová, Marie (1)Charousová, Markéta (1)Duben, Jakub (1)Eckschlager, Tomáš (1)... View MoreSubjectAnthracyclines (1)Cancer (1)Chemoresistance (1)chemoresistance of cancer cells (1)Chemotherapeutics (1)Cisplatin (1)Ferritin (1)fluorogenic detection (1)Homing peptide (1)homology modeling (1)... View MoreDate Issued
2020 (5)

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