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Study of Linkage between Glutathione Pathway and the Antibiotic Resistance of Escherichia coli from Patients’ Swabs
(MDPI, 2015-05-31)
V této práci jsme se zaměřili na rozdíly mezi bakteriálních kultur E. coli, získaných ze stěrů infekčních ran pacientů ve srovnání s laboratorním E. coli. Navíc blokování proteinu odpovědné za syntézu glutathion ...
Surface PEGylation and PASylation to regulate nanoparticle interactions with biological environment
(Mendel University in Brno, 2017-12-31)
Many researchers are developing nanocarriers in order to minimalize side effects of cytotoxic drugs during cancer treatment via chemotherapy. Nanocarriers can serve as a suitable platform for targeted drug delivery. To ...
Sarcosine degradation pathway is involved in the epigenetics of prostate cells
(Mendel University in Brno, 2017-12-31)
It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine ...
The Zinc-Schiff Base-Novicidin Complex as a Potential Prostate Cancer Therapy
(PLOS, 2016-10-11)
Prostate cancer cells control energy metabolism by chelating intracellular zinc. Thus, zinc
delivery has been a popular therapeutic approach for prostate cancer. Here, we propose
the use of the membrane-penetrating peptide ...
Sarcosine up-regulates expression of genes involved in cell cycle progression of metastatic models of prostate cancer
(PLOS, 2016-11-08)
The effects of sarcosine on the processes driving prostate cancer (PCa) development remain still unclear. Herein, we show that a supplementation of metastatic PCa cells (androgen independent PC-3 and androgen dependent ...
Nanoparticles Suitable for BCAA Isolation Can Serve for Use in Magnetic Lipoplex-Based Delivery System for L, I, V, or R-rich Antimicrobial Peptides
(MDPI, 2016-04-01)
This paper investigates the synthesis of paramagnetic nanoparticles, which are able to bind branched chain amino acids (BCAAs)—leucine, valine, and isoleucine and, thus, serve as a tool for their isolation. Further, by ...
Prostate tumor attenuation in the nu/nu murine model due to antisarcosine antibodies in folate targeted liposomes
(Nature Publishing Group, 2016-09-20)
Herein, we describe the preparation of liposomes with folate-targeting properties for the
encapsulation of anti-sarcosine antibodies (antisarAbs@LIP) and sarcosine (sar@LIP). The competitive
inhibitory effects of exogenously ...
Apoferritin as an ubiquitous nanocarrier with excellent shelf life
(Dove Media Press, 2017-03-24)
Due to many adverse effects of conventional chemotherapy, novel methods of targeting drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for this specific delivery. Herein, we evaluated ...
Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration
(Springer Nature, 2017-01-10)
We describe a new procedure for the parallel mapping of selected metals in histologically characterized
tissue samples. Mapping is achieved via image registration of digital data obtained from two
neighbouring cryosections ...
Targeting Neuroblastoma Cell Surface Proteins: Recommendations for Homology Modeling of hNET, ALK, and TrkB
(Frontiers, 2017-01-20)
Targeted therapy is a promising approach for treatment of neuroblastoma as evident
from the large number of targeting agents employed in clinical practice today. In
the absence of known crystal structures, researchers rely ...