Now showing items 11-20 of 1052
Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells
(Impact Journals, 2016-08-19)
Treatment options for TP53-mutated lymphoid tumors are very limited. In experimental models, TP53-mutated lymphomas were sensitive to direct inhibition of checkpoint kinase 1 (Chk1), a pivotal regulator of replication. We ...
Migrastatics—anti-metastatic and anti-invasion drugs: promises and challenges
In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we ...
Distinctive behaviour of live biopsy-derived carcinoma cells unveiled using coherence-controlled holographic microscopy
Head and neck squamous cell carcinoma is one of the most aggressive tumours and is typically diagnosed too late. Late diagnosis requires an urgent decision on an effective therapy. An individualized test of chemosensitivity ...
Local Treatment of Hand-Foot Syndrome with Uridine/Thymidine:In Vitro Appraisal on a Human Keratinocyte Cell Line HaCaT
5-fluorouracil (5-FU) is one of the most commonly used antineoplastic drugs in the anticancer therapy. The hand-foot (HF) syndrome (palmar-plantar erythrodysesthesia) is an adverse effect frequently related to long-term ...
On a close to symmetric system of difference equations of second order
(Springer Nature, 2015-12-29)
Closed form formulas of the solutions to the system of difference equations of the second order are found. The domain of undefinable solutions to the system is described.
On a product-type system of difference equations of second order solvable in closed form
(BioMed Central, 2015-10-12)
Sufficient conditions for solving a system of difference equations of second order in closed form are given. Moreover, sufficient conditions for existence of periodic solutions and asymptotic stability of solutions are ...
Boundedness character of a fourth-order system of difference equations
(Springer Nature, 2015-12-01)
Sufficient conditions for boundedness character of solutions of a fourth-order system of difference equations is given.
A multi-mode cantilever singular point detection using adaptive hypothesis testing
(IOP Publishing, 2015-10-05)
Fundamental analysis of a multi-mode model of the atomic force microscope cantilever shows that at some points; called here singular points, the mode is vanished. Consequently, the order of the input/output behavior is ...
Laser induced phase transition in epitaxial FeRh layers studied by pump-probe valence band photoemission
(AIP Publishing, 2018-05-01)
We use time-resolved X-ray photoelectron spectroscopy to probe the electronic and magnetization dynamics in FeRh films after ultrafast laser excitations. We present experimental and theoretical results which investigate ...
Magnetization reversal and confinement effects across the metamagnetic phase transition in mesoscale FeRh structures
(IOP PUBLISHING LTD, 2018-03-14)
The effects of mesoscale confinement on the metamagnetic behavior of lithographically patterned FeRh structures are investigated via Kerr microscopy. Combining the temperatureand field-dependent magnetization reversal of ...