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dc.contributor.authorBrabenec, Lubošcs
dc.contributor.authorKlobušiaková, Patríciacs
dc.contributor.authorŠimko, Patrikcs
dc.contributor.authorKošťálová, Milenacs
dc.contributor.authorMekyska, Jiřícs
dc.contributor.authorRektorová, Irenacs
dc.date.accessioned2021-12-14T15:55:53Z
dc.date.available2021-12-14T15:55:53Z
dc.date.issued2021-05-01cs
dc.identifier.citationBRAIN STIMUL. 2021, vol. 14, issue 3, p. 571-578.en
dc.identifier.issn1935-861Xcs
dc.identifier.other171119cs
dc.identifier.urihttp://hdl.handle.net/11012/203212
dc.description.abstractBackground: Hypokinetic dysarthria is a common but difficult-to-treat symptom of Parkinson’s disease (PD). Objectives: We evaluated the long-term effects of multiple-session repetitive transcranial magnetic stimulation on hypokinetic dysarthria in PD. Neural mechanisms of stimulation were assessed by functional MRI. Methods: A randomized parallel-group sham stimulation-controlled design was used. Patients were randomly assigned to ten sessions (2 weeks) of real (1 Hz) or sham stimulation over the right superior temporal gyrus. Stimulation effects were evaluated at weeks 2, 6, and 10 after the baseline assessment. Articulation, prosody, and speech intelligibility were quantified by speech therapist using a validated tool (Phonetics score of the Dysarthric Profile). Activations of the speech network regions and intrinsic connectivity were assessed using 3T MRI. Linear mixed models and post-hoc tests were utilized for data analyses. Results: Altogether 33 PD patients completed the study (20 in the real stimulation group and 13 in the sham stimulation group). Linear mixed models revealed significant effects of time (F(3, 88.1) = 22.7, p < 0.001) and time-by-group interactions: F(3, 88.0) = 2.8, p = 0.040) for the Phonetics score. Real as compared to sham stimulation led to activation increases in the orofacial sensorimotor cortex and caudate nucleus and to increased intrinsic connectivity of these regions with the stimulated area. Conclusions: This is the first study to show the long-term treatment effects of non-invasive brain stimulation for hypokinetic dysarthria in PD. Neural mechanisms of the changes are discussed.en
dc.formattextcs
dc.format.extent571-578cs
dc.format.mimetypeapplication/pdfcs
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofBRAIN STIMULcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1935861X21000619cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectParkinson’s diseaseen
dc.subjecthypokinetic dysarthriaen
dc.subjectrTMSen
dc.subjectfMRIen
dc.subjectdorsal language pathwayen
dc.titleNon-invasive brain stimulation for speech in Parkinson’s disease: A randomized controlled trialen
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav telekomunikacícs
sync.item.dbidVAV-171119en
sync.item.dbtypeVAVen
sync.item.insts2021.12.14 16:55:53en
sync.item.modts2021.12.14 16:15:25en
dc.coverage.issue3cs
dc.coverage.volume14cs
dc.identifier.doi10.1016/j.brs.2021.03.010cs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1935-861X/cs
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen


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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International