Ratiometric pH-Responsive F-19 Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches
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Hydrazone-based molecular switches serve as eflicient ratiometric pH-sensitive agents that can be tracked with F-19 NMR/MRI and H-1 NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at H-1 and F-19 NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF3 group shifted by 1.8 ppm with F-19 NMR and a hydrazone proton shifted by 2 ppm with H-1 NMR.
KeywordsMagnetic resonance imaging, Fluorine, pH, Molecular structure, Nuclear magnetic resonance spectroscopy
Document typePeer reviewed
Document versionFinal PDF
SourceAnalytical Chemistry. 2022, vol. 94, issue 8, p. 3427-3431.