Now showing items 257-276 of 314

  • Sarcosine as a potential prostate cancer biomarker – A review 

    Cernei, Natalia Vladimirovna; Heger, Zbyněk; Gumulec, Jaromír; Zítka, Ondřej; Masařík, Michal; Babula, Petr; Eckschlager, Tomáš; Stiborová, Marie; Kizek, René; Adam, Vojtěch (MDPI, 2013-07-04)
    Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that ...
  • Sarcosine degradation pathway is involved in the epigenetics of prostate cells 

    Strmiska, Vladislav; Michálek, Petr; Buchtelová, Hana; Lacková, Zuzana; Guráň, Roman; Křížková, Soňa; Pompeiano Vaníčková, Lucie; Zítka, Ondřej; Stiborová, Marie; Eckschlager, Tomáš; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2017-12-31)
    It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine ...
  • Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe-Dnmts axis 

    Strmiska, Vladislav; Michálek, Petr; Lacková, Zuzana; Guráň, Roman; Křížková, Soňa; Pompeiano Vaníčková, Lucie; Zítka, Ondřej; Stiborová, Marie; Eckschlager, Tomáš; Klejdus, Bořivoj; Pacík, Dalibor; Tvrdíková, Eliška; Keil, Claudia; Haase, Hajo; Adam, Vojtěch; Heger, Zbyněk (FEBS Press, 2019-05-31)
    DNA hypermethylation is one of the most common epigenetic modifications in prostate cancer (PCa). Several studies have delineated sarcosine as a PCa oncometabolite that increases the migration of malignant prostate cells ...
  • Sarcosine up-regulates expression of genes involved in cell cycle progression of metastatic models of prostate cancer 

    Heger, Zbyněk; Merlos Rodrigo, Miguel Ángel; Michálek, Petr; Polanská, Hana; Masařík, Michal; Vít, Vítězslav; Plevová, Mariana; Pacík, Dalibor; Eckschlager, Tomáš; Stiborová, Marie; Adam, Vojtěch (PLOS, 2016-11-08)
    The effects of sarcosine on the processes driving prostate cancer (PCa) development remain still unclear. Herein, we show that a supplementation of metastatic PCa cells (androgen independent PC-3 and androgen dependent ...
  • Selective Laser Melting Strategy for Fabrication of Thin Struts Usable in Lattice Structures 

    Vrána, Radek; Koutný, Daniel; Paloušek, David; Pantělejev, Libor; Jaroš, Jan; Zikmund, Tomáš; Kaiser, Jozef (MDPI, 2018-09-18)
    This paper deals with the selective laser melting (SLM) processing strategy for strut-lattice structure production which uses only contour lines and allows the porosity and roughness level to be managed based on ombination ...
  • Selectively arranged single-wire based nanosensor array systems for gas monitoring 

    Chmela, Ondřej; Sadílek, Jakub; Somer, Jakub; Mohan, Rajneesh; Hubálek, Jaromír; Vallejos Vargas, Stella (Royal Society of Chemistry, 2018-05-01)
    Gas nanosensors, comprised of arrays of nanoelectrodes with finger-widths of ~100 nm developed by electron beam lithography and aerosol assisted chemical vapor deposited non-functionalized and Pt-functionalized tungsten ...
  • Self-Ordered TiO2 Quantum Dot Array Prepared via Anodic Oxidation 

    Drbohlavová, Jana; Hrdý, Radim; Salyk, Ota; Kizek, René; Hubálek, Jaromír (SpringerOpen, 2012-02-14)
    The paper brings the important information about synthesis of titania quantum dots in the form of sensor array which is suitable for various biomolecules (DNA, proteins) sensing in vitro. The usage of this fluorescence ...
  • Sensitive biosensor for detection oncogenic miRNA-21 

    Vaňová, Veronika; Sedláčková, Eliška; Hynek, David; Richtera, Lukáš; Adam, Vojtěch (Mendel University in Brno, 2019-12-31)
    The aim of this study was to prepare a sensitive electrochemical biosensor for detection of oncogenic miRNA-21 as a potential biomarker for early detection of cancer. MicroRNAs (miRNAs) are small noncoding RNA, which play ...
  • Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis 

    Gumulec, Jaromír; Masařík, Michal; Adam, Vojtěch; Eckschlager, Tomáš; Provazník, Ivo; Kizek, René (PLOS, 2014-06-19)
    Background and Objectives: Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized ...
  • Serum metallothioneins in childhood tumours – A potential prognostic marker 

    Kruseová, Jarmila; Hynek, David; Adam, Vojtěch; Kizek, René; Průša, Richard; Hraběta, Jan; Eckschlager, Tomáš (MDPI, 2013-06-06)
    Metallothioneins (MT) are low molecular weight, cysteine-rich proteins maintaining metal ions homeostasis. They play a role in carcinogenesis and may also cause chemoresistance. The aim of the study was to explore the ...
  • Sharka: The Past, The Present and The Future 

    Sochor, Jiří; Babula, Petr; Adam, Vojtěch; Krška, Boris; Kizek, René (MDPI, 2012-11-01)
    Members the Potyviridae family belong to a group of plant viruses that are causing devastating plant diseases with a significant impact on agronomy and economics. Plum pox virus (PPV), as a causative agent of sharka disease, ...
  • Simple and efficient AlN-based piezoelectric energy harvesters 

    Gablech, Imrich; Klempa, Jaroslav; Pekárek, Jan; Vyroubal, Petr; Hrabina, Jan; Holá, Miroslava; Kunz, Jan; Brodský, Jan; Neužil, Pavel (MDPI, 2020-01-28)
    In this work, we demonstrate the simple fabrication process of AlN-based piezoelectric energy harvesters (PEH), which are made of cantilevers consisting of a multilayer ion beam-assisted deposition. The preferentially (001) ...
  • Simple criterion for predicting fatigue life under combined bending and torsion loading 

    Slámečka, Karel; Pokluda, Jaroslav (Gruppo Italiano Frattura, 2017-07-01)
    Multiaxial fatigue is a challenging problem and, consequently, a number of methods has been developed to aid in design of components and assemblies. Following the complexity of the problem, these approaches are often ...
  • A simple electrochemical biosensor for the detection of methylated DNA and for methyltransferase activity monitoring 

    Sedláčková, Eliška; Smolíková, Vendula; Birgusová, Eliška; Bytešníková, Zuzana; Richtera, Lukáš; Adam, Vojtěch (Mendel University in Brno, 2019-12-31)
    DNA methylation is one of the well-known epigenetic mechanism which plays a crucial role in the development of various diseases, such as cancer, cardiovascular diseases or diabetes. Electrochemical biosensors promise ...
  • Simulink Generated Control Algorithm for Nine-phase PMS Motor 

    Kozovský, Matúš; Blaha, Petr (IEEE, 2017-11-24)
    This paper deals with the nine-phase motor control algorithm development, mainly with its implementation in target hardware using MATLAB Simulink. This environment allows control algorithm design using model based approach ...
  • Simultaneous Automatic Electrochemical Detection of Zinc, Cadmium, Copper and Lead Ions in Environmental Samples Using a Thin-Film Mercury Electrode and an Artificial Neural Network 

    Kudr, Jiří; Nguyen, Hoai Viet; Gumulec, Jaromír; Nejdl, Lukáš; Blažková, Iva; Ruttkay-Nedecký, Branislav; Hynek, David; Kynický, Jindřich; Adam, Vojtěch; Kizek, René (MDPI, 2015-01-01)
    In this study a device for automatic electrochemical analysis was designed. A three electrodes detection system was attached to a positioning device, which enabled us to move the electrode system from one well to another ...
  • Single Fluorescence Channel-based Multiplex Detection of Avian Influenza Virus by Quantitative PCR with Intercalating Dye 

    Ahrberg, Christian D.; Manz, Andreas; Neužil, Pavel (Nature Publishing Group, 2015-06-19)
    Since its invention in 1985 the polymerase chain reaction (PCR) has become a well-established method for amplification and detection of segments of double-stranded DNA. Incorporation of fluorogenic probe or DNA intercalating ...
  • Soluble collagen dissolution and assembling in pressurized carbon dioxide water solutions 

    Zubal, Lukáš; Bonani, Walter; Maniglio, Devid; Ceccato, Riccardo; Renčiuk, Daniel; Hampl, Aleš; Migliaresi, Claudio; Jančář, Josef; Vojtová, Lucy (Budapest University of Technology, 2018-02-01)
    Dissolution and gelation procedures have a great influence on gelation time, microstructure and mechanical properties of reconstituted collagen products. We have investigated the dissolution of atelocollagen in CO2/water ...
  • Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration 

    Adam, Vojtěch; Heger, Zbyněk (Springer Nature, 2017-01-10)
    We describe a new procedure for the parallel mapping of selected metals in histologically characterized tissue samples. Mapping is achieved via image registration of digital data obtained from two neighbouring cryosections ...
  • Specific Magnetic Isolation of E6 HPV16 Modified Magnetizable Particles Coupled with PCR and Electrochemical Detection 

    Jimenez Jimenez, Ana Maria; Ruttkay-Nedecký, Branislav; Dostálová, Simona; Krejčová, Ludmila; Richtera, Lukáš; Adam, Vojtěch; Michálek, Petr (MDPI, 2016-05-01)
    The majority of carcinomas that were developed due to the infection with human papillomavirus (HPV) are caused by high-risk HPV types, HPV16 and HPV18. These HPV types contain the E6 and E7 oncogenes, so the fast detection ...