Now showing items 1-6 of 6
In Vitro Interactions between 17 beta-Estradiol and DNA Result in Formation of the Hormone-DNA Complexes
Beyond the role of 17 beta-estradiol (E-2) in reproduction and during the menstrual cycle, it has been shown to modulate numerous physiological processes such as cell proliferation, apoptosis, inflammation and ion transport ...
The Role of Metallothionein in Oxidative Stress
Volné radikály jsou chemické částice, které obsahují jeden nebo více nepárových elektronů, které mohou být součástí molekuly. Způsobují, že se molekula stává velmi reaktivní. Volné radikály jsou také známo, že hrají dvojí ...
Apoferritin-mediated doxorubicin internalization through transferrin receptor 1
(Mendel University in Brno, 2017-12-31)
This work is aimed at the possibilities of targeted drug delivery into the tumour tissue. This approach can greatly reduce the otherwise serious side effects of conventional treatment - systemic toxicity. For this purpose, ...
Modulation of Induced Cytotoxicity of Doxorubicin by Using Apoferritin and Liposomal Cages
Doxorubicin is an effective chemotherapeutic drug, however, its toxicity is a significant limitation in therapy. Encapsulation of doxorubicin inside liposomes or ferritin cages decreases cardiotoxicity while maintaining ...
Microfluidic Technology for Clinical Applications of Exosomes
Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as ...
Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma
(Springer Nature, 2021-03-09)
Metallothionein-3 has poorly characterized functions in neuroblastoma. Cisplatin-based chemotherapy is a major regimen to treat neuroblastoma, but its clinical efficacy is limited by chemoresistance. We investigated the ...