Chytré nanonástroje
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Peptide-carbon quantum dots conjugate, derived from human Retinoic Acid Receptor Responder Protein 2, against antibiotic-resistant gram positive and gram negative pathogenic bacteria
(MDPI, 2020-02-28)Antibiotic-resistant bacterial infections have become global issues for public health, which increases the utter need to develop alternatives to antibiotics. Here, the HSER (Homo sapiens retinoic acid receptor) peptide was ... -
Love wave sensors based on gold nanoparticle-modified polypyrrole and their properties to ammonia and ethylene
(Elsevier, 2020-02-01)This work presents the fabrication and gas sensing properties of Love wave sensors based on non-modified and gold nanoparticle-modified polypyrrole. Results demonstrate the integration of uniform polypyrrole layers with ... -
Infinite selectivity of wet SiO2 etching in respect to Al
(MDPI, 2020-03-31)We propose and demonstrate an unconventional method suitable for releasing microelectromechanical systems devices containing an Al layer by wet etching using SiO2 as a sacrificial layer. We used 48% HF solution in combination ... -
Simple and efficient AlN-based piezoelectric energy harvesters
(MDPI, 2020-01-28)In this work, we demonstrate the simple fabrication process of AlN-based piezoelectric energy harvesters (PEH), which are made of cantilevers consisting of a multilayer ion beam-assisted deposition. The preferentially (001) ... -
Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation
(NATURE PUBLISHING GROUP, 2019-02-07)We focused on the biomechanical and morphological characteristics of prostate cancer cells and their changes resulting from the effect of docetaxel, cisplatin, and long-term zinc supplementation. Cell population surviving ... -
DEP-on-a-Chip: Dielectrophoresis Applied to Microfluidic Platforms
(MDPI, 2019-06-24)Dielectric particles in a non-uniform electric field are subject to a force caused by a phenomenon called dielectrophoresis (DEP). DEP is a commonly used technique in microfluidics for particle or cell separation. In ... -
Microfluidic Technology for Clinical Applications of Exosomes
(MDPI, 2019-06-12)Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as ... -
The effect of different fatty acid sources on wound healing in rats assessed by matrix-assisted-laser-desorption-ionization mass-spectroscopy-imaging
(University of Veterinary and Pharmaceutical Sciences in Brno, 2019-12-01)The objective of the present study was to compare the effects of dietary oils containing polyunsaturated fatty acids (PUFA) n-3 and n-6, respectively, on cutaneous wound healing in rats, and to demonstrate the usefulness ... -
Optimization of multiplex RT-PCR for selected isoforms of metallothionein genes and influence of cisplatin on prostatic cell lines
(Mendel University in Brno, 2019-12-31)This study deals with the issue of metallothioneins as potential tumor markers using the multiplex reverse transcription polymerase chain reaction (RT-PCR) method, for which specific primers were designed, with the subsequent ... -
A non-enzymatic sensor for sensitive determination of H2O2 using biomimetic nanocomposite
(Mendel University in Brno, 2019-12-31)Hydrogen peroxide (H2O2), as a critical secondary messenger, is important for in vitro and in vivo study. In addition, it is of great significance in monitoring the biological condition under chemical oxidative stress. A ... -
Biogenic amines modified carbon quantum dots as antibacterial agent
(Mendel University in Brno, 2019-12-31)An alternative to conventional way is needed to treat multiple drug resistant bacteria. In this work, four different amine modified carbon quantum dots (CQDs) were obtained by microwave irradiation treatment. The four ... -
Nanocomposite furcellaran films - The influence of nanofillers on functional properties of furcellaran films and effect on linseed oil preservation
(MDPI, 2019-12-09)Nanocomposite films that were based on furcellaran (FUR) and nanofillers (carbon quantum dots (CQDs), maghemite nanoparticles (MAN), and graphene oxide (GO)) were obtained by the casting method. The microstructure, as well ... -
Synthesis of zinc selenium-based nanoparticles modified by algal oil and their effect on bacterial growth
(Mendel University in Brno, 2019-12-31)The aim of this study was to develop suitable zinc selenium-based nanoparticles modified by algal oil containing mainly polyunsaturated fatty acids. Dietary omega-6 and omega-3 polyunsaturated fatty acids can affect ... -
LA-ICP-MS as a sensitive method for detection of nanoparticle-antibody conjugates in immunochemistry analysis
(Mendel University in Brno, 2019-12-31)Laser ablation followed by inductively coupled plasma mass spectrometry is an analytical method suitable for low concentration measurement of elements in a sample. This can be used not only for detection of elemental ... -
Determination of arsenic bioavailability in mineral springs in the Czech Republic
(Mendel University in Brno, 2019-12-31)Mineral springs Hronovka and Regnerka located in the northeast Bohemia, Czech Republic are characteristic for high content of arsenic. The diffusive gradient in thin films technique (DGT) was used for determination of ... -
Effect of sarcosine dehydrogenase knockdown on sarcosine metabolism-related genes expression
(Mendel University in Brno, 2019-12-31)Sarcosine is extensively discussed as potential prostate cancer oncometabolite. Sarcosine dehydrogenase (SARDH) is one of the key enzymes involved in sarcosine metabolism that catalyses oxidative demethylation of sarcosine ... -
Sensitive biosensor for detection oncogenic miRNA-21
(Mendel University in Brno, 2019-12-31)The aim of this study was to prepare a sensitive electrochemical biosensor for detection of oncogenic miRNA-21 as a potential biomarker for early detection of cancer. MicroRNAs (miRNAs) are small noncoding RNA, which play ... -
Novel Ruthenium coordinate compound combined with Schiff base and benzimidazole as a potent antibacterial agent against VRSA and MRSA
(Mendel University in Brno, 2019-12-31)The rise of antibiotic-resistant strains is an important public health problem and thus the development of an alternative to antibiotics is imminent. The Ruthenium–Schiff base with benzimidazole (RU–S2), a co-ordinate ... -
A simple electrochemical biosensor for the detection of methylated DNA and for methyltransferase activity monitoring
(Mendel University in Brno, 2019-12-31)DNA methylation is one of the well-known epigenetic mechanism which plays a crucial role in the development of various diseases, such as cancer, cardiovascular diseases or diabetes. Electrochemical biosensors promise ... -
Modification of Zinc Selenium nanoparticles with fish oil and their effect on bacteria
(Mendel University in Brno, 2019-12-31)The aim of this study was develop suitable nanomaterial modified by fish oil using microwave-assisted synthesis. Dietary omega-6 and omega-3 polyunsaturated fatty acids can influence an inflammatory process, as well as ...
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