Now showing items 132-142 of 142

  • Targeting Neuroblastoma Cell Surface Proteins: Recommendations for Homology Modeling of hNET, ALK, and TrkB 

    Haddad, Yazan Abdulmajeed Eyadh; Heger, Zbyněk; Adam, Vojtěch (Frontiers, 2017-01-20)
    Targeted therapy is a promising approach for treatment of neuroblastoma as evident from the large number of targeting agents employed in clinical practice today. In the absence of known crystal structures, researchers rely ...
  • Transcriptomic landscape of cisplatin-resistant neuroblastoma cells 

    Merlos Rodrigo, Miguel Ángel; Buchtelová, Hana; Jimenez Jimenez, Ana Maria; Adam, Pavlína; Babula, Petr; Heger, Zbyněk; Adam, Vojtěch (MDPI, 2019-03-31)
    The efficiency of cisplatin (CDDP) is significantly hindered by the development of resistance during the treatment course. To gain a detailed understanding of the molecular mechanisms underlying the development of cisplatin ...
  • Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity 

    Kopel, Pavel; Doležal, Karel; Langer, Vratislav; Jun, Daniel; Adam, Vojtěch; Kuča, Kamil; Kizek, René (MDPI, 2014-04-08)
    The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH3) were prepared and characterized by elemental analysis and ...
  • Trk receptors and neurotrophins cross-interactions: New perspective to manipulating therapeutic side-effects 

    Haddad, Yazan Abdulmajeed Eyadh; Adam, Vojtěch; Heger, Zbyněk (Frontiers, 2017-05-03)
    Some therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons ...
  • Utilization of antibody-nanoparticle conjugates as a tool for immunochemistry with ICP-MS detection 

    Vlčnovská, Marcela; Tvrdoňová, Michaela; Vaculovičová, Markéta; Vaculovič, Tomáš (Mendel University in Brno, 2019-01-02)
    Immunoanalytical techniques are key methods of application in clinical diagnostics, genomics, proteomics and other biochemical and molecular biology disciplines. Most often, they are based on the ability of labeled antibodies ...
  • Voltammetry as a Tool for Characterization of CdTe Quantum Dots 

    Adam, Pavlína; Vaculovičová, Markéta; Hubálek, Jaromír; Adam, Vojtěch; Kizek, René (MDPI, 2013-06-27)
    Electrochemical detection of quantum dots (QDs) has already been used in numerous applications. However, QDs have not been well characterized using voltammetry, with respect to their characterization and quantification. ...
  • Water-dispersible TiO2 nanoparticles via a biphasic solvothermal reaction method 

    Mohan, Rajneesh; Drbohlavová, Jana; Hubálek, Jaromír (Springer, 2013-12-01)
    A biphasic solvothermal reaction method has been used for the synthesis of TiO2 nanoparticles (NPs). In this method, hydrolysis and nucleation occur at the interface of organic phase (titanium (IV) n-propoxide and stearic acid ...
  • Zinc phosphate nanoparticles as an antimicrobial agent and their impact on rats microbiota 

    Kočiová, Silvia; Bytešníková, Zuzana; Horký, Pavel; Kopel, Pavel; Adam, Vojtěch; Šmerková, Kristýna (Mendel University in Brno, 2019-01-02)
    Nano minerals, especially trace minerals, are widely used in different fields, but mostly in animal systems. They can improve overall immunity and also a digestive efficacy in livestock. In this case, nanometals as nano ...
  • Zinc Phosphate Nanoparticles Preparation and Their Antimicrobial Activity 

    Kopel, Pavel; Cernei, Natalia Vladimirovna; Gagić, Milica; Horký, Pavel; Šmerková, Kristýna; Adam, Vojtěch (Tanger, 2019-02-01)
    Zinc phosphate particles were prepared by reaction of zinc nitrate with hydrogen phosphate, diphosphate and triphosphate, and characterized by Dynamic Light scattering (DLS) and Scanning Electron Microscopy (SEM). Antibacterial ...
  • Zinc phosphate-based nanoparticles as a novel antibacterial agent: in vivo study on rats after dietary exposure 

    Horký, Pavel; Skaličková, Sylvie; Urbánková, Lenka; Baholet, Daria; Kočiová, Silvia; Bytešníková, Zuzana; Kabourková, Eliška; Lacková, Zuzana; Cernei, Natalia Vladimirovna; Gagić, Milica; Milosavljević, Vedran; Smolíková, Vendula; Václavková, Eva; Nevrkla, Pavel; Knot, Pavel; Kryštofová, Olga; Hynek, David; Kopel, Pavel; Skládanka, Jiří; Adam, Vojtěch; Šmerková, Kristýna (BioMed Central, 2019-02-12)
    Background: Development of new nanomaterials that inhibit or kill bacteria is an important and timely research topic. For example, financial losses due to infectious diseases, such as diarrhea, are a major concern in ...
  • The Zinc-Schiff Base-Novicidin Complex as a Potential Prostate Cancer Therapy 

    Milosavljević, Vedran; Haddad, Yazan Abdulmajeed Eyadh; Merlos Rodrigo, Miguel Ángel; Moulick, Amitava; Polanská, Hana; Hynek, David; Heger, Zbyněk; Kopel, Pavel; Adam, Vojtěch (PLOS, 2016-10-11)
    Prostate cancer cells control energy metabolism by chelating intracellular zinc. Thus, zinc delivery has been a popular therapeutic approach for prostate cancer. Here, we propose the use of the membrane-penetrating peptide ...