Browsing Chytré nanonástroje by Title

Now showing items 1-20 of 142

  • A 3D Microfluidic Chip for Electrochemical Detection of Hydrolysed Nucleic Bases by a Modified Glassy Carbon Electrode 

    Vlachová, Jana; Tmejová, Kateřina; Kopel, Pavel; Korabík, Michal; Zítka, Jan; Hynek, David; Kynický, Jindřich; Adam, Vojtěch; Kizek, René (MDPI AG, POSTFACH, CH-4005 BASEL, SWITZERLAND, 2015-02-01)
    Modification of carbon materials, especially graphene-based materials, has wide applications in electrochemical detection such as electrochemical lab-on-chip devices. A glassy carbon electrode (GCE) modified with chemically ...

  • An Acetylcholinesterase-Based Chronoamperometric Biosensor for Fast and Reliable Assay of Nerve Agents 

    Pohanka, Miroslav; Adam, Vojtěch; Kizek, René (MDPI, 2013-09-01)
    The enzyme acetylcholinesterase (AChE) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. It is sensitive to inhibition by organophosphate ...

  • Algal Biomass Analysis by Laser-Based Analytical Techniques - A Review 

    Pořízka, Pavel; Prochazková, Petra; Prochazka, David; Sládková, Lucia; Novotný, Jan; Petrilak, Michal; Brada, Michal; Samek, Ota; Pilát, Zdeněk; Zemánek, Pavel; Adam, Vojtěch; Kizek, René; Novotný, Karel; Kaiser, Jozef (MDPI AG, 2014-09-23)
    Algal biomass that is represented mainly by commercially grown algal strains has recently found many potential applications in various fields of interest. Its utilization has been found advantageous in the fields of ...

  • Amalgam electrode-based electrochemical detector for on-site direct determination of cadmium(II) and lead(II) from soils 

    Nejdl, Lukáš; Kynický, Jindřich; Brtnický, Martin; Vaculovičová, Markéta; Adam, Vojtěch (MDPI, 2017-08-01)
    Toxic metal contamination of the environment is a global issue. In this paper, we present a low-cost and rapid production of amalgam electrodes used for determination of Cd(II) and Pb(II) in environmental samples (soils ...

  • Anticancerogenic effect of spices due to phenolic and flavonoid compounds – in vitro evaluation on prostate cells 

    Lacková, Zuzana; Buchtelová, Hana; Buchtová, Žaneta; Klejdus, Bořivoj; Heger, Zbyněk; Brtnický, Martin; Kynický, Jindřich; Zítka, Ondřej; Adam, Vojtěch (MDPI, 2017-09-28)
    This study shows the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines (PNT1A, 22RV1 and PC3). The results of an MTT assay on extracts from eight spices revealed the strongest inhibitory ...

  • Antimicrobial activity of CdTe QDs modified with lanthanides on pseudomonas aeruginosa 

    Jelínková, Pavlína; Koudelková, Zuzana; Kopel, Pavel; Moulick, Amitava; Adam, Vojtěch (Mendel University in Brno, 2017-12-31)
    The aim of this study is to obtain data based on an experimental procedure and check the effectiveness of some antibacterial agents against pathogenic bacteria. In the present experiment, two different nanoparticles (Cadmium ...

  • Antioxidant activity of yoghurt supplemented with natural additives 

    Ananbeh, Hanadi Abd Al Rahman Ali; Voběrková, Stanislava; Kumbár, Vojtěch (Mendel University in Brno, 2017-12-31)
    The aims of this study were the estimation of difference in physiochemical properties and antioxidant activity of yoghurts supplemented by different natural additives. In addition, the changes in physiochemical properties ...

  • Antioxidant response of arabidopsis thaliana to ZnSe-nanoparticles, selenium and zinc ions 

    Koláčková, Martina; Moulick, Amitava; Klejdus, Bořivoj; Húska, Dalibor (Mendel University in Brno, 2017-12-31)
    The impact of zinc selenide nanoparticles (ZnSe-NPs) on plants is still unknown. The intention of this work was to compare phytotoxicity of ZnSe-NPs and selenium and zinc ions in 100, 250 and 500 M concentrations. Young ...

  • Antioxidant status of rats’ blood and liver affected by sodium selenite and selenium nanoparticles 

    Urbánková, Lenka; Horký, Pavel; Skládanka, Jiří; Přibilová, Magdalena; Smolíková, Vendula; Nevrkla, Pavel; Cernei, Natalia Vladimirovna; Lacková, Zuzana; Hedbávný, Josef; Ridošková, Andrea; Adam, Vojtěch; Kopel, Pavel (PeerJ, 2018-05-28)
    Background: Selenium is an essential element; however, at higher doses, it can be toxic. Therefore, alternative nanotechnological solutions are required to overcome toxicological issues, rather than conventional alternatives. ...

  • Apoferritin as an ubiquitous nanocarrier with excellent shelf life 

    Dostálová, Simona; Vašíčková, Kateřina; Hynek, David; Křížková, Soňa; Richtera, Lukáš; Vaculovičová, Markéta; Eckschlager, Tomáš; Stiborová, Marie; Heger, Zbyněk; Adam, Vojtěch (Dove Media Press, 2017-03-24)
    Due to many adverse effects of conventional chemotherapy, novel methods of targeting drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for this specific delivery. Herein, we evaluated ...

  • Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery 

    Blažková, Iva; Nguyen, Hoai Viet; Dostálová, Simona; Kopel, Pavel; Stanisavljevic, Maja; Vaculovičová, Markéta; Stiborová, Marie; Eckschlager, Tomáš; Kizek, René; Adam, Vojtěch (MDPI, 2013-06-27)
    Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation ...

  • Apoferritin-mediated doxorubicin internalization through transferrin receptor 1 

    Krausová, Kateřina; Dostálová, Simona; Hynek, David; Křížková, Soňa; Adam, Vojtěch; Heger, Zbyněk (Mendel University in Brno, 2017-12-31)
    This work is aimed at the possibilities of targeted drug delivery into the tumour tissue. This approach can greatly reduce the otherwise serious side effects of conventional treatment - systemic toxicity. For this purpose, ...

  • The application of capillary electrophoresis, mass spectrometry and Brdicka reaction in human and rabbit metallothioneins analysis 

    Kepinska, Marta; Křížková, Soňa; Guszpit, Ewelina; Merlos Rodrigo, Miguel Ángel; Milnerowicz, Halina (Wroclaw Medical University, 2018-11-30)
    Background. Metallothioneins (MTs) constitute a family of evolutionary conserved low molecular weight proteins with small variations in their amino acid sequences. They play a role in the regulation of trace metals metabolism, ...

  • Application of the Enzymatic Electrochemical Biosensors for Monitoring Non-Competitive Inhibition of Enzyme Activity by Heavy Metals 

    Amirmansoor, Ashrafi; Sýs, Milan; Sedláčková, Eliška; Farag, Amir Shaaban; Adam, Vojtěch; Přibyl, Jan; Richtera, Lukáš (MDPI, 2019-07-03)
    The inhibition effect of the selected heavy metals (Ag+, Cd2+, Cu2+, and Hg2+) on glucose oxidase (GOx) enzyme from Aspergillus niger (EC 1.1.3.4.) was studied using a new amperometric biosensor with an electrochemical ...

  • Are Early Somatic Embryos of the Norway Spruce (Picea abies (L.) Karst.) Organised? 

    Petřek, Jiří; Zítka, Ondřej; Adam, Vojtěch; Bartušek, Karel; Anjum, Naser A.; Pereira, Eduarda; Havel, Ladislav; Kizek, René (PLOS, 2015-12-01)
    Somatic embryogenesis in conifer species has great potential for the forestry industry. Hence, a number of methods have been developed for their efficient and rapid propagation through somatic embryogenesis. Although ...

  • Beads-Based Electrochemical Assay for the Detection of Influenza Hemagglutinin Labeled with CdTe Quantum Dots 

    Krejčová, Ludmila; Nejdl, Lukáš; Hynek, David; Křížková, Soňa; Kopel, Pavel; Adam, Vojtěch; Kizek, René (MDPI, 2013-12-13)
    In this study we describe a beads-based assay for rapid, sensitive and specific isolation and detection of influenza vaccine hemagglutinin (HA). Amplification of the hemagglutinin signal resulted from binding of an ...

  • Behaviour of zinc complexes and zinc sulphide nanoparticles revealed by using screen printed electrodes and spectrometry 

    Nejdl, Lukáš; Ruttkay-Nedecký, Branislav; Kudr, Jiří; Kremplová, Monika; Cernei, Natalia Vladimirovna; Prášek, Jan; Konečná, Marie; Hubálek, Jaromír; Zítka, Ondřej; Kynický, Jindřich; Kopel, Pavel; Kizek, René; Adam, Vojtěch (MDPI AQ, 2013-10-25)
    In this study, we focused on microfluidic electrochemical analysis of zinc complexes (Zn(phen)(his)Cl-2, Zn(his)Cl-2) and ZnS quantum dots (QDs) using printed electrodes. This method was chosen due to the simple (easy to ...

  • Bio-Sensing of Cadmium(II) Ions Using Staphylococcus aureus 

    Sochor, Jiří; Zítka, Ondřej; Hynek, David; Krejčová, Ludmila; Trnková, Libuše; Adam, Vojtěch; Hubálek, Jaromír; Kynický, Jindřich; Vrba, Radimír; Kizek, René (MDPI, 2011-11-08)
    Cadmium, as a hazardous pollutant commonly present in the living environment, represents an important risk to human health due to its undesirable effects (oxidative stress, changes in activities of many enzymes, interactions ...

  • Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes 

    Kopel, Pavel; Wawrzak, Dorota; Langer, Vratislav; Číhalová, Kristýna; Hegerová, Dagmar; Veselý, Radek; Adam, Vojtěch; Kizek, René (MDPI, 2015-06-01)
    1-(1H-Benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methanamine (abb) and 2-(1H-benzimidazol-2-ylmethylsulfanylmethyl)-1H-benzimidazole (tbb) have been prepared and characterized by elemental analysis. These bis(benzimidazoles) ...

  • Capillary Blood GSH Level Monitoring, Using an Electrochemical Method Adapted for Micro Volumes 

    Buchtová, Žaneta; Lacková, Zuzana; Kudr, Jiří; Zítka, Zdeněk; Škoda, Jan; Zítka, Ondřej (MDPI, 2018-10-01)
    Glutathione (gamma-glutamyl-cysteinyl-glycine; also known as GSH) is an endogenous antioxidant that plays a crucial role in cell defense mechanisms against oxidative stress. It is thus not surprising that this molecule can ...