Ústav biomedicínského inženýrství
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Autophagy modulators influence the content of important signalling molecules in PS-positive extracellular vesicles
(BMC, 2023-05-24)Extracellular vesicles (EVs) are important mediators of intercellular communication in the tumour microenvironment. Many studies suggest that cancer cells release higher amounts of EVs exposing phosphatidylserine (PS) at ... -
A multi-color video-ophthalmoscopes allows to measure the spectral distribution of light absorption of blood in the human retina
(Frontiers, 2023-03-16)Based on our previously developed mono-color video-ophthalmoscope a multi-color video-ophthalmoscope was developed. Using narrow band transmission filters, this instrument allows to measure the pulsatile cardiac cycle ... -
Physics-informed deep learning approach to quantification of human brain metabolites from magnetic resonance spectroscopy data
(Elsevier, 2023-04-05)Purpose: While the recommended analysis method for magnetic resonance spectroscopy data is linear combination model (LCM) fitting, the supervised deep learning (DL) approach for quantification of MR spectroscopy (MRS) and ... -
Bipolar anodal septal pacing with direct LBB capture preserves physiological ventricular activation better than unipolar left bundle branch pacing
(Frontiers, 2023-03-22)BackgroundLeft bundle branch pacing (LBBP) produces delayed, unphysiological activation of the right ventricle. Using ultra-high-frequency electrocardiography (UHF-ECG), we explored how bipolar anodal septal pacing with ... -
Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications
(Springer Nature, 2023-03-10)The interest in NK cells and their cytotoxic activity against tumour, infected or transformed cells continuously increases as they become a new efficient and off-the-shelf agents in immunotherapies. Their actions are ... -
Comparative analysis of retinal photoplethysmographic spatial maps and thickness of retinal nerve fiber layer
(PUBLIC LIBRARY SCIENCE, 2023-05-05)The paper presents a comparative study of the pulsatile attenuation amplitude (PAA) within the optic nerve head (ONH) at four different areas calculated from retinal video sequences and its relevance to the retinal nerve ... -
Assessment of retinal vein pulsation through video-ophthalmoscopy and simultaneous biosignals acquisition
(Optica Publishing Group, 2023-05-12)The phenomenon of retinal vein pulsation is still not a deeply understood topic in retinal hemodynamics. In this paper, we present a novel hardware solution for recording retinal video sequences and physiological signals ... -
Comprehensive automatic processing and analysis of adaptive optics flood illumination retinal images on healthy subjects
(Optica Publishing Group, 2023-01-30)This work presents a novel fully automated method for retinal analysis in images acquired with a flood illuminated adaptive optics retinal camera (AO-FIO). The proposed processing pipeline consists of several steps: First, ... -
Rapid Identification of Pseudomonas aeruginosa International High-Risk Clones Based on High-Resolution Melting Analysis
(American Society for Microbiology, 2023-01-11)The Pseudomonas aeruginosa population has a nonclonal epidemic structure. It is generally composed of a limited number of widespread clones selected from a background of many rare and unrelated genotypes recombining at ... -
Interpretable machine learning methods for predictions in systems biology from omics data
(Frontiers, 2022-10-17)Machine learning has become a powerful tool for systems biologists, from diagnosing cancer to optimizing kinetic models and predicting the state, growth dynamics, or type of a cell. Potential predictions from complex ... -
Using deep learning for gene detection and classification in raw nanopore signals
(Frontiers Media SA, 2022-09-15)Recently, nanopore sequencing has come to the fore as library preparation is rapid and simple, sequencing can be done almost anywhere, and longer reads are obtained than with next-generation sequencing. The main bottleneck ... -
Weakly Supervised Deep Learning-based Intracranial Hemorrhage Localization
(SciTePress, 2022-03-01)Intracranial hemorrhage is a life-threatening disease, which requires fast medical intervention. Owing to the duration of data annotation, head CT images are usually available only with slice-level labeling. However, ... -
Comparison of Stranded and Non-stranded RNA-Seq in Predicting Small RNAs in a Non-model Bacterium
(Springer Nature, 2022-06-08)Thanks to their diversity, non-model bacteria represent an inexhaustible resource for microbial biotechnology. Their utilization is only limited by our lack of knowledge regarding the regulation of processes they are capable ... -
Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context
(Frontiers Media, 2022-04-25)Cardiovascular system and its functions under both physiological and pathophysiological conditions have been studied for centuries. One of the most important steps in the cardiovascular research was the possibility to ... -
Heart rate and age modulate retinal pulsatile patterns
(NATURE PORTFOLIO, 2022-06-14)Video-recordings of retinal pulsatile patterns in human eye are modulated by heart rate and age. This invivo evidence fundamentally impacts modeling of retinal function and clinical design in wide range of medical specialties. ... -
Reliable P wave detection in pathological ECG signals
(Springer Nature, 2022-04-21)Accurate automated detection of P waves in ECG allows to provide fast correct diagnosis of various cardiac arrhythmias and select suitable strategy for patients' treatment. However, P waves detection is a still challenging ... -
Characterisation of Waterborne Psychrophilic Massilia Isolates with Violacein Production and Description of Massilia antarctica sp. nov.
(MDPI, 2022-03-24)A group of seven bacterial strains producing blue-purple pigmented colonies on R2A agar was isolated from freshwater samples collected in a deglaciated part of James Ross Island and Eagle Island, Antarctica, from 2017-2019. ... -
Possibilities of Reducing Radiation Dose in Computed Tomography Examinations in Various Age Groups Using an Iterative Model-Based Reconstruction Technique
(OMICS International, 2016-11-04)Aim: To determine whether iterative model-based reconstruction (IMR) technique can preserve computed tomography (CT) image quality when the radiation dose is reduced to 20% of the original value. Methods: CT examination ... -
Incorporation of Low Concentrations of Gold Nanoparticles: Complex Effects on Radiation Response and Fate of Cancer Cells
(MDPI, 2022-01-11)(1) Background: In oncology research, a long-standing discussion exists about pros and cons of metal nanoparticle-enhanced radiotherapy and real mechanisms behind the tumor cell response to irradiation (IR) in presence of ... -
Experimental Evaluation of Dry Powder Inhalers during Inhalation and Exhalation Using a Model of the Human Respiratory System (xPULM™)
(MDPI, 2022-02-24)Dry powder inhalers are used by a large number of patients worldwide to treat respiratory diseases. The objective of this work is to experimentally investigate changes in aerosol particle diameter and particle number ...
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