Now showing items 1-2 of 2

  • Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds 

    Palušová, Veronika; Renzová, Tereza; Verlande, Amandine; Vaclová, Tereza; Medková, Michaela; Cetlová, Linda; Sedláčková, Miroslava; Hříbková, Hana; Slaninová, Iva; Krutá, Miriama; Rotrekl, Vladimír; Uhlířová, Hana; Křížová, Aneta; Chmelík, Radim; Veselý, Pavel; Krafčíková, Michaela; Trantírek, Lukáš; Schink, Kay Oliver; Uldrijan, Stjepan (MDPI, 2020-06-01)
    BRAF inhibitors can delay the progression of metastatic melanoma, but resistance usually emerges, leading to relapse. Drugs simultaneously targeting two or more pathways essential for cancer growth could slow or prevent ...
  • Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion 

    Tolde, Ondřej; Gandalovičová, Aneta; Křížová, Aneta; Veselý, Pavel; Chmelík, Radim; Rösel, Daniel; Brábek, Jan (Springer Nature, 2018-08-13)
    Observation and analysis of cancer cell behaviour in 3D environment is essential for full understanding of the mechanisms of cancer cell invasion. However, label-free imaging of live cells in 3D conditions is optically ...