Browsing Ústav fyzikálního inženýrství by Subject "analogy purinových nukleosidů"
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Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells (Impact Journals, 2016-08-19)Treatment options for TP53-mutated lymphoid tumors are very limited. In experimental models, TP53-mutated lymphomas were sensitive to direct inhibition of checkpoint kinase 1 (Chk1), a pivotal regulator of replication. We ...