Browsing Ústav fyzikálního inženýrství by Subject "checkpoint kinase 1/Chk1"
Now showing items 1-1 of 1
Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells (Impact Journals, 2016-08-19)Treatment options for TP53-mutated lymphoid tumors are very limited. In experimental models, TP53-mutated lymphomas were sensitive to direct inhibition of checkpoint kinase 1 (Chk1), a pivotal regulator of replication. We ...