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dc.contributor.authorKoščová, Pavlína
dc.date.accessioned2018-07-10T12:48:19Z
dc.date.available2018-07-10T12:48:19Z
dc.date.issued2016cs
dc.identifier.citationProceedings of the 22nd Conference STUDENT EEICT 2016. s. 523-527. ISBN 978-80-214-5350-0cs
dc.identifier.isbn978-80-214-5350-0
dc.identifier.urihttp://hdl.handle.net/11012/83988
dc.description.abstractThe number of drug-resistant strains of Borrelia burgdorferi necessitated the identification of potential drug targets specific to the strain of interest. The chromosomal and plasmid genes of B. burgdorferi strain B31 were compared with erythromycin-resistant B. burgdorferi strain N40 to find common (core) and unique (strain-specific) genes in present study. In silico analysis of genomic data showed total number of unique genes higher in strain N40. The presence of higher number of unique genes in N40 signifies their role in drug resistance mechanism. Furthermore, human proteome was compared with proteome of these strains to find target protein specific to the strain of interest and not present in host. In conclusion, identification of unique genes in these strains provided on differences in drug resistance potential.en
dc.formattextcs
dc.format.extent523-527cs
dc.format.mimetypeapplication/pdfen
dc.language.isoencs
dc.publisherVysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologiícs
dc.relation.ispartofProceedings of the 22nd Conference STUDENT EEICT 2016en
dc.relation.urihttp://www.feec.vutbr.cz/EEICT/cs
dc.rights© Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologiícs
dc.subjectBorrelia burgdorferien
dc.subjectLyme diseaseen
dc.subjecterythromycinen
dc.subjectresistanceen
dc.titleComparative Analysis of Common and Unique Targets in Drug Resistant Strain of Borrelia Burgdorferien
eprints.affiliatedInstitution.departmentFakulta elektrotechniky a komunikačních technologiícs
but.event.date28.04.2016cs
but.event.titleStudent EEICT 2016cs
dc.rights.accessopenAccessen
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen


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