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Effect of the selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells

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MendelNet_mnt2017010103.pdf (450.7Kb)
Date
2017-12-31
Author
Lacková, Zuzana
Buchtelová, Hana
Buchtová, Žaneta
Adam, Vojtěch
Zítka, Ondřej
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Abstract
In this study, the effect of selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells (PNT1A, 22RV1 and PC3) was observed. Synthetic standards of 3,4-dihydroxybenzaldehyde and naringenin chalcone, identified previously by HPLC-MS in black pepper seeds extracts, and neochlorogenic acid and apigenin, identified in caraway seeds extracts, were applied. For the evaluation of the potential inhibitory effect of selected compounds on PNT1A, 22RV1 and PC3 cells, the clonogenic assay and the microscopic observation of cells were done. The results of clonogenic assay showed that phenolic compounds had the strongest inhibitory effect on 22RV1 and PC3 cells, while the flavonoid compounds had the strongest inhibitory effect on PNT1A cells.
Keywords
Spices, clonogenic assay, phenolic compounds, flavonoid compounds, prostate cell lines
Persistent identifier
http://hdl.handle.net/11012/84188
Document type
Peer reviewed
Document version
Final PDF
Source
MendelNet 2017. 2017, p. 900-904.
https://mendelnet.cz/artkey/mnt-201701-0103_Effect-of-the-selected-phenolic-and-flavonoid-compounds-of-black-pepper-and-caraway-seeds-on-prostate-cells.php?back=/magno/mnt/2017/mn1.php?secid=4
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  • Chytré nanonástroje [215]
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