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hNET as a target for neuroblastoma nanomedicine
(Mendel University in Brno, 2017-12-31)
Chemotherapy often results in various side effects, which can negatively affect health. Neuroblastoma, one of the most common types of childhood cancer, is but one of the examples, where side effects of chemotherapeutic ...
Surface PEGylation and PASylation to regulate nanoparticle interactions with biological environment
(Mendel University in Brno, 2017-12-31)
Many researchers are developing nanocarriers in order to minimalize side effects of cytotoxic drugs during cancer treatment via chemotherapy. Nanocarriers can serve as a suitable platform for targeted drug delivery. To ...
Sarcosine degradation pathway is involved in the epigenetics of prostate cells
(Mendel University in Brno, 2017-12-31)
It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine ...
Nanoparticles Suitable for BCAA Isolation Can Serve for Use in Magnetic Lipoplex-Based Delivery System for L, I, V, or R-rich Antimicrobial Peptides
(MDPI, 2016-04-01)
This paper investigates the synthesis of paramagnetic nanoparticles, which are able to bind branched chain amino acids (BCAAs)—leucine, valine, and isoleucine and, thus, serve as a tool for their isolation. Further, by ...
Prostate tumor attenuation in the nu/nu murine model due to antisarcosine antibodies in folate targeted liposomes
(Nature Publishing Group, 2016-09-20)
Herein, we describe the preparation of liposomes with folate-targeting properties for the
encapsulation of anti-sarcosine antibodies (antisarAbs@LIP) and sarcosine (sar@LIP). The competitive
inhibitory effects of exogenously ...
Apoferritin as an ubiquitous nanocarrier with excellent shelf life
(Dove Media Press, 2017-03-24)
Due to many adverse effects of conventional chemotherapy, novel methods of targeting drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for this specific delivery. Herein, we evaluated ...
Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer
(MDPI, 2016-03-17)
Herein, we present a study focused on the determination of the influence of long-distance
(53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa)
biomarkers total prostate-specific ...
Improving cytocompatibility of CdTe quantum dots by Schiff-base-coordinated lanthanides surface doping
(BioMed Central, 2018-04-19)
Background: Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable ...
Prostate-Specific Membrane Antigen-Targeted Site-Directed Antibody-Conjugated Apoferritin Nanovehicle Favorably Influences In Vivo Side Effects of Doxorubicin
(Springer Nature, 2018-06-11)
Herein, we describe the in vivo effects of doxorubicin (DOX) encapsulated in ubiquitous protein apoferritin (APO) and its efficiency and safety in anti-tumor treatment. APODOX is both passively (through Enhanced Permeability ...
Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors
(The International Institute of Anticancer Research, 2018-04-01)
Background: Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of ...