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dc.contributor.authorMinsterová, Alžbětacs
dc.contributor.authorKlobušiaková, Patríciacs
dc.contributor.authorPieš, Adriáncs
dc.contributor.authorGaláž, Zoltáncs
dc.contributor.authorMekyska, Jiřícs
dc.contributor.authorNováková, Ľubomíracs
dc.contributor.authorElfmarkova, Nelacs
dc.contributor.authorRektorová, Irenacs
dc.date.accessioned2021-01-13T15:56:43Z
dc.date.available2021-01-13T15:56:43Z
dc.date.issued2020-10-19cs
dc.identifier.citationPARKINSONISM & RELATED DISORDERS. 2020, vol. 81, issue 1, p. 96-102.en
dc.identifier.issn1353-8020cs
dc.identifier.other165726cs
dc.identifier.urihttp://hdl.handle.net/11012/195850
dc.description.abstractBackground: Diffusion kurtosis imaging has been applied to evaluate white matter and basal ganglia microstructure in mixed Parkinson's disease (PD) groups with inconclusive results. Objectives: To evaluate specific patterns of kurtosis changes in PD and to assess the utility of diffusion imaging in differentiating between healthy subjects and cognitively normal PD, and between PD with and without mild cognitive impairment. Methods: Diffusion scans were obtained in 92 participants using 3T MRI. Differences in white matter were tested by tract-based spatial statistics. Gray matter was evaluated in basal ganglia, thalamus, hippocampus, and motor and premotor cortices. Brain atrophy was also assessed. Multivariate logistic regression was used to identify a combination of diffusion parameters with the highest discrimination power between groups. Results: Diffusion kurtosis metrics showed a significant increase in substantia nigra (p = 0.037, Hedges' g = 0.89), premotor (p = 0.009, Hedges' g = 0.85) and motor (p = 0.033, Hedges' g = 0.87) cortices in PD with normal cognition compared to healthy participants. Combined diffusion markers in gray matter reached 81% accuracy in differentiating between both groups. Significant white matter microstructural changes, and kurtosis decreases in the cortex were present in cognitively impaired versus cognitively normal PD. Diffusion parameters from white and gray matter differentiated between both PD phenotypes with 78% accuracy. Conclusions: Increased kurtosis in gray matter structures in cognitively normal PD reflects increased hindrance to water diffusion caused probably by alpha-synuclein-related microstructural changes. In cognitively impaired PD, the changes are mostly driven by decreased white matter integrity. Our results support the utility of diffusion kurtosis imaging for PD diagnostics.en
dc.formattextcs
dc.format.extent96-102cs
dc.format.mimetypeapplication/pdfcs
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofPARKINSONISM & RELATED DISORDERScs
dc.relation.urihttps://www.prd-journal.com/article/S1353-8020(20)30825-7/fulltextcs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectMRIen
dc.subjectdiffusion kurtosis imagingen
dc.subjectParkinson's diseaseen
dc.subjectmild cognitive impairmenten
dc.subjectdiagnostic markeren
dc.titlePatterns of diffusion kurtosis changes in Parkinson's disease subtypesen
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav telekomunikacícs
sync.item.dbidVAV-165726en
sync.item.dbtypeVAVen
sync.item.insts2021.01.31 12:58:45en
sync.item.modts2021.01.31 12:15:52en
dc.coverage.issue1cs
dc.coverage.volume81cs
dc.identifier.doi10.1016/j.parkreldis.2020.10.032cs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1353-8020/cs
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen


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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International