Poslední příspěvky

  • G-Quadruplexes as Sensing Probes 

    Ruttkay-Nedecký, Branislav; Kudr, Jiří; Nejdl, Lukáš; Mašková, Darina; Kizek, René; Adam, Vojtěch (MDPI, 2013-12-01)
    Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. ...
  • Sharka: The Past, The Present and The Future 

    Sochor, Jiří; Babula, Petr; Adam, Vojtěch; Krška, Boris; Kizek, René (MDPI, 2012-11-01)
    Members the Potyviridae family belong to a group of plant viruses that are causing devastating plant diseases with a significant impact on agronomy and economics. Plum pox virus (PPV), as a causative agent of sharka disease, ...
  • Construction of an acetylcholinesterase sensor based on synthesized paramagnetic nanoparticles, a simple tool for neurotoxic compounds assay 

    Kostelník, Adam; Kopel, Pavel; Čegan, Alexander; Pohanka, Miroslav (MDPI, 2017-04-30)
    Magnetic particles (MPs) have been widely used in biological applications in recent years as a carrier for various molecules. Their big advantage is in repeated use of immobilized molecules including enzymes. Acetylcholinesterase ...
  • An Acetylcholinesterase-Based Chronoamperometric Biosensor for Fast and Reliable Assay of Nerve Agents 

    Pohanka, Miroslav; Adam, Vojtěch; Kizek, René (MDPI, 2013-09-01)
    The enzyme acetylcholinesterase (AChE) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. It is sensitive to inhibition by organophosphate ...
  • Mathematical evaluation of the amino acid and polyphenol content and antioxidant activities of fruits from different apricot cultivars 

    Sochor, Jiří; Škutková, Helena; Babula, Petr; Zítka, Ondřej; Cernei, Natalia Vladimirovna; Rop, Otakar; Krška, Boris; Adam, Vojtěch; Provazník, Ivo; Kizek, René (MDPI, 2011-09-01)
    Functional foods are of interest because of their significant effects on human health, which can be connected with the presence of some biologically important compounds. In this study, we carried out complex analysis of ...
  • Development of a magnetic electrochemical bar code array for point mutation detection in the H5N1 neuraminidase gene 

    Krejčová, Ludmila; Hynek, David; Kopel, Pavel; Merlos Rodrigo, Miguel Ángel; Adam, Vojtěch; Hubálek, Jaromír; Babula, Petr; Trnková, Libuše; Kizek, René (MDPI, 2013-07-15)
    Since its first official detection in the Guangdong province of China in 1996, the highly pathogenic avian influenza virus of H5N1 subtype (HPAI H5N1) has reportedly been the cause of outbreaks in birds in more than 60 ...
  • A New Method for 2D Materials Properties Modulation by Controlled Induced Mechanical Strain 

    Gablech, Imrich; Pekárek, Jan; Klempa, Jaroslav; Vyroubal, Petr; Svatoš, Vojtěch; Neužil, Pavel (MDPI, 2018-12-07)
    This paper proposes a new method for characterization of 2D materials under the precisely specified conditions. It is achieved by integration of a 2D material as a field effect transistors structures with a piezoelectric ...
  • A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin 

    Heger, Zbyněk; Cernei, Natalia Vladimirovna; Kudr, Jiří; Gumulec, Jaromír; Blažková, Iva; Zítka, Ondřej; Eckschlager, Tomáš; Stiborová, Marie; Adam, Vojtěch; Kizek, René (MDPI, 2013-11-01)
    Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated ...
  • Resistive switching in TiO2 nanocolumn arrays electrochemically grown 

    Márik, Marian; Mozalev, Alexander; Hubálek, Jaromír; Bendová, Mária (IOP Publishing, 2017-04-21)
    Resistive switching in metal oxides, especially in TiO2, has been intensively investigated for potential application in non-volatile memory microdevices. As one of the working mechanisms, a conducting filament consisting ...
  • Novel Vancomycin-Peptide Conjugate as Potent Antibacterial Agent against Vancomycin-Resistant Staphylococcus aureus 

    Jelínková, Pavlína; Šplíchal, Zbyněk; Jimenez Jimenez, Ana Maria; Haddad, Yazan Abdulmajeed Eyadh; Mazumdar, Aninda; Sur, Vishma Pratap; Milosavljević, Vedran; Kopel, Pavel; Buchtelová, Hana; Guráň, Roman; Zítka, Ondřej; Richtera, Lukáš; Hegerová, Dagmar; Heger, Zbyněk; Moulick, Amitava; Adam, Vojtěch (Dove Press, 2018-11-01)
    Background: Increase in vancomycin (Van)-resistant bacterial strains including vancomycin-resistant Staphylococcus aureus (VRSA) and lack of new effective antibiotics have become a formidable health problem. Materials and ...
  • Selectively arranged single-wire based nanosensor array systems for gas monitoring 

    Chmela, Ondřej; Sadílek, Jakub; Somer, Jakub; Mohan, Rajneesh; Hubálek, Jaromír; Vallejos Vargas, Stella (Royal Society of Chemistry, 2018-05-01)
    Gas nanosensors, comprised of arrays of nanoelectrodes with finger-widths of ~100 nm developed by electron beam lithography and aerosol assisted chemical vapor deposited non-functionalized and Pt-functionalized tungsten ...
  • Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer 

    Heger, Zbyněk; Gumulec, Jaromír; Ondrák, Aleš; Škoda, Jan; Zítka, Zdeněk; Cernei, Natalia Vladimirovna; Masařík, Michal; Zítka, Ondřej; Adam, Vojtěch (MDPI, 2016-03-17)
    Herein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific ...
  • Paramagnetic Nanoparticles as a Platform for FRET-Based Sarcosine Picomolar Detection 

    Heger, Zbyněk; Cernei, Natalia Vladimirovna; Křížková, Soňa; Masařík, Michal; Kopel, Pavel; Hodek, Petr; Zítka, Ondřej; Adam, Vojtěch; Kizek, René (Nature Publishing Group, 2015-03-09)
    Herein, we describe an ultrasensitive specific biosensing system for detection of sarcosine as a potential biomarker of prostate carcinoma based on Forster resonance energy transfer (FRET). The FRET biosensor employs ...
  • Effect of zinc-selenium nanoparticles on microalgae scenedesmus quadricauda 

    Strejčková, Aneta; Koláčková, Martina; Vaněčková, Tereza; Býtešníková, Zuzana; Moulick, Amitava; Rankić, Ivan; Klejdus, Bořivoj; Húska, Dalibor (Mendel University in Brno, 2017-12-31)
    The increasing industrial use of nanomaterials in recent years poses a potential risk to the environment. The first organisms that come into contact with these substances include aquatic organisms, and therefore this study ...
  • Platinum nanoparticles induce damage to DNA and inhibit DNA replication 

    Nejdl, Lukáš; Kudr, Jiří; Moulick, Amitava; Hegerová, Dagmar; Ruttkay-Nedecký, Branislav; Gumulec, Jaromír; Číhalová, Kristýna; Šmerková, Kristýna; Dostálová, Simona; Křížková, Soňa; Novotná, Marie; Kopel, Pavel; Adam, Vojtěch (PLOS, 2017-07-12)
    Sparsely tested group of platinum nanoparticles (PtNPs) may have a comparable effect as complex platinum compounds. The aim of this study was to observe the effect of PtNPs in in vitro amplification of DNA fragment of phage ...
  • Nanostructured Polypyrrole-Based Ammonia and Volatile Organic Compound Sensors 

    Šetka, Milena; Drbohlavová, Jana; Hubálek, Jaromír (MDPI, 2017-03-10)
    The aim of this review is to summarize the recent progress in the fabrication of efcient nanostructured polymer-based sensors with special focus on polypyrrole. The correlation between physico-chemical parameters, mainly ...
  • Sarcosine as a potential prostate cancer biomarker – A review 

    Cernei, Natalia Vladimirovna; Heger, Zbyněk; Gumulec, Jaromír; Zítka, Ondřej; Masařík, Michal; Babula, Petr; Eckschlager, Tomáš; Stiborová, Marie; Kizek, René; Adam, Vojtěch (MDPI, 2013-07-04)
    Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that ...
  • Molecular imprinting technology for targeted analysis of proteins 

    Hutařová, Jitka; Vaněčková, Tereza; Vaculovičová, Markéta; Adam, Vojtěch (Mendel University in Brno, 2017-12-31)
    Molecular imprinting has appeared to be an effective technique for creating of selective recognition sites in synthetic polymers. This procedure comprises polymerization of monomer in a presence of target molecules (template). ...
  • Effect of the selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells 

    Lacková, Zuzana; Buchtelová, Hana; Buchtová, Žaneta; Adam, Vojtěch; Zítka, Ondřej (Mendel University in Brno, 2017-12-31)
    In this study, the effect of selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells (PNT1A, 22RV1 and PC3) was observed. Synthetic standards of 3,4-dihydroxybenzaldehyde and naringenin ...
  • Antimicrobial activity of CdTe QDs modified with lanthanides on pseudomonas aeruginosa 

    Jelínková, Pavlína; Koudelková, Zuzana; Kopel, Pavel; Moulick, Amitava; Adam, Vojtěch (Mendel University in Brno, 2017-12-31)
    The aim of this study is to obtain data based on an experimental procedure and check the effectiveness of some antibacterial agents against pathogenic bacteria. In the present experiment, two different nanoparticles (Cadmium ...

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