Now showing items 1-20 of 106

  • Carbon composite micro- and nano-tubes-based electrodes for detection of nucleic acids 

    Prášek, Jan; Húska, Dalibor; Trnková, Libuše; Adam, Vojtěch; Kizek, René; Hubálek, Jaromír (Springer, 2011-05-16)
    The first aim of this study was to fabricate vertically aligned multiwalled carbon nanotubes (MWCNTs). MWCNTs were successfully prepared by using plasma enhanced chemical vapour deposition. Further, three carbon composite ...
  • Mathematical evaluation of the amino acid and polyphenol content and antioxidant activities of fruits from different apricot cultivars 

    Sochor, Jiří; Škutková, Helena; Babula, Petr; Zítka, Ondřej; Cernei, Natalia Vladimirovna; Rop, Otakar; Krška, Boris; Adam, Vojtěch; Provazník, Ivo; Kizek, René (MDPI, 2011-09-01)
    Functional foods are of interest because of their significant effects on human health, which can be connected with the presence of some biologically important compounds. In this study, we carried out complex analysis of ...
  • Bio-Sensing of Cadmium(II) Ions Using Staphylococcus aureus 

    Sochor, Jiří; Zítka, Ondřej; Hynek, David; Krejčová, Ludmila; Trnková, Libuše; Adam, Vojtěch; Hubálek, Jaromír; Kynický, Jindřich; Vrba, Radimír; Kizek, René (MDPI, 2011-11-08)
    Cadmium, as a hazardous pollutant commonly present in the living environment, represents an important risk to human health due to its undesirable effects (oxidative stress, changes in activities of many enzymes, interactions ...
  • Self-Ordered TiO2 Quantum Dot Array Prepared via Anodic Oxidation 

    Drbohlavová, Jana; Hrdý, Radim; Salyk, Ota; Kizek, René; Hubálek, Jaromír (SpringerOpen, 2012-02-14)
    The paper brings the important information about synthesis of titania quantum dots in the form of sensor array which is suitable for various biomolecules (DNA, proteins) sensing in vitro. The usage of this fluorescence ...
  • Sharka: The Past, The Present and The Future 

    Sochor, Jiří; Babula, Petr; Adam, Vojtěch; Krška, Boris; Kizek, René (MDPI, 2012-11-01)
    Members the Potyviridae family belong to a group of plant viruses that are causing devastating plant diseases with a significant impact on agronomy and economics. Plum pox virus (PPV), as a causative agent of sharka disease, ...
  • Modern Micro and Nanoparticle-Based Imaging Techniques 

    Vaculovičová, Markéta; Pekárková, Jana; Drbohlavová, Jana; Kopel, Pavel; Babula, Petr; Hynek, David; Adam, Vojtěch; Eckschlager, Tomáš; Hubálek, Jaromír; Stiborová, Marie; Kaiser, Jozef; Kizek, René (MDPI, 2012-11-02)
    The requirements for early diagnostics as well as effective treatment of insidious diseases such as cancer constantly increase the pressure on development of efficient and reliable methods for targeted drug/gene delivery ...
  • Effect of Magnetic Nanoparticles on Tobacco BY-2 Cell Suspension Culture 

    Kryštofová, Olga; Sochor, Jiří; Zítka, Ondřej; Babula, Petr; Kudrle, Vít; Adam, Vojtěch; Kizek, René (MDPI, 2013-01-01)
    Nanomaterials are structures whose exceptionality is based on their large surface, which is closely connected with reactivity and modification possibilities. Due to these properties nanomaterials are used in textile industry ...
  • The Role of Metallothionein in Oxidative Stress 

    Ruttkay-Nedecký, Branislav; Nejdl, Lukáš; Gumulec, Jaromír; Zítka, Ondřej; Masařík, Michal; Eckschlager, Tomáš; Stiborová, Marie; Adam, Vojtěch; Kizek, René (MDPI, 2013-03-15)
    Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in ...
  • Ion exchange chromatography and mass spectrometric methods for analysis of cadmium-phytochelatin (II) complexes 

    Merlos Rodrigo, Miguel Ángel; Cernei, Natalia Vladimirovna; Komínková, Markéta; Zítka, Ondřej; Beklová, Miroslava; Zehnálek, Josef; Kizek, René; Adam, Vojtěch (MDPI, 2013-03-28)
    In this study, in vitro formed Cd-phytochelatin (PC2) complexes were characterized using ion exchange chromatography (IEC) and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. The ...
  • Serum metallothioneins in childhood tumours – A potential prognostic marker 

    Kruseová, Jarmila; Hynek, David; Adam, Vojtěch; Kizek, René; Průša, Richard; Hraběta, Jan; Eckschlager, Tomáš (MDPI, 2013-06-06)
    Metallothioneins (MT) are low molecular weight, cysteine-rich proteins maintaining metal ions homeostasis. They play a role in carcinogenesis and may also cause chemoresistance. The aim of the study was to explore the ...
  • Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery 

    Blažková, Iva; Nguyen, Hoai Viet; Dostálová, Simona; Kopel, Pavel; Stanisavljevic, Maja; Vaculovičová, Markéta; Stiborová, Marie; Eckschlager, Tomáš; Kizek, René; Adam, Vojtěch (MDPI, 2013-06-27)
    Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation ...
  • Voltammetry as a Tool for Characterization of CdTe Quantum Dots 

    Adam, Pavlína; Vaculovičová, Markéta; Hubálek, Jaromír; Adam, Vojtěch; Kizek, René (MDPI, 2013-06-27)
    Electrochemical detection of quantum dots (QDs) has already been used in numerous applications. However, QDs have not been well characterized using voltammetry, with respect to their characterization and quantification. ...
  • Complexes of silver(I) ions and silver phosphate nanoparticles with hyaluronic acid and/or chitosan as promising antimicrobial agents for vascular grafts 

    Hegerová, Dagmar; Nejdl, Lukáš; Gumulec, Jaromír; Kryštofová, Olga; Merlos Rodrigo, Miguel Ángel; Kynický, Jindřich; Ruttkay-Nedecký, Branislav; Kopel, Pavel; Babula, Petr; Adam, Vojtěch; Kizek, René (MDPI, 2013-06-28)
    Polymers are currently widely used to replace a variety of natural materials with respect to their favourable physical and chemical properties, and due to their economic advantage. One of the most important branches of ...
  • Sarcosine as a potential prostate cancer biomarker – A review 

    Cernei, Natalia Vladimirovna; Heger, Zbyněk; Gumulec, Jaromír; Zítka, Ondřej; Masařík, Michal; Babula, Petr; Eckschlager, Tomáš; Stiborová, Marie; Kizek, René; Adam, Vojtěch (MDPI, 2013-07-04)
    Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that ...
  • Development of a magnetic electrochemical bar code array for point mutation detection in the H5N1 neuraminidase gene 

    Krejčová, Ludmila; Hynek, David; Kopel, Pavel; Merlos Rodrigo, Miguel Ángel; Adam, Vojtěch; Hubálek, Jaromír; Babula, Petr; Trnková, Libuše; Kizek, René (MDPI, 2013-07-15)
    Since its first official detection in the Guangdong province of China in 1996, the highly pathogenic avian influenza virus of H5N1 subtype (HPAI H5N1) has reportedly been the cause of outbreaks in birds in more than 60 ...
  • An Acetylcholinesterase-Based Chronoamperometric Biosensor for Fast and Reliable Assay of Nerve Agents 

    Pohanka, Miroslav; Adam, Vojtěch; Kizek, René (MDPI, 2013-09-01)
    The enzyme acetylcholinesterase (AChE) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. It is sensitive to inhibition by organophosphate ...
  • Behaviour of zinc complexes and zinc sulphide nanoparticles revealed by using screen printed electrodes and spectrometry 

    Nejdl, Lukáš; Ruttkay-Nedecký, Branislav; Kudr, Jiří; Kremplová, Monika; Cernei, Natalia Vladimirovna; Prášek, Jan; Konečná, Marie; Hubálek, Jaromír; Zítka, Ondřej; Kynický, Jindřich; Kopel, Pavel; Kizek, René; Adam, Vojtěch (MDPI AQ, 2013-10-25)
    In this study, we focused on microfluidic electrochemical analysis of zinc complexes (Zn(phen)(his)Cl-2, Zn(his)Cl-2) and ZnS quantum dots (QDs) using printed electrodes. This method was chosen due to the simple (easy to ...
  • A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin 

    Heger, Zbyněk; Cernei, Natalia Vladimirovna; Kudr, Jiří; Gumulec, Jaromír; Blažková, Iva; Zítka, Ondřej; Eckschlager, Tomáš; Stiborová, Marie; Adam, Vojtěch; Kizek, René (MDPI, 2013-11-01)
    Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated ...
  • Water-dispersible TiO2 nanoparticles via a biphasic solvothermal reaction method 

    Mohan, Rajneesh; Drbohlavová, Jana; Hubálek, Jaromír (Springer, 2013-12-01)
    A biphasic solvothermal reaction method has been used for the synthesis of TiO2 nanoparticles (NPs). In this method, hydrolysis and nucleation occur at the interface of organic phase (titanium (IV) n-propoxide and stearic acid ...
  • G-Quadruplexes as Sensing Probes 

    Ruttkay-Nedecký, Branislav; Kudr, Jiří; Nejdl, Lukáš; Mašková, Darina; Kizek, René; Adam, Vojtěch (MDPI, 2013-12-01)
    Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. ...