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Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis

dc.contributor.authorGumulec, Jaromírcs
dc.contributor.authorMasařík, Michalcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorEckschlager, Tomášcs
dc.contributor.authorProvazník, Ivocs
dc.contributor.authorKizek, Renécs
dc.date.accessioned2016-11-08T16:28:47Z
dc.date.available2016-11-08T16:28:47Z
dc.date.issued2014-06-19cs
dc.identifier.citationPLOS ONE. 2014, vol. 9, issue 6, p. 1-11.en
dc.identifier.issn1932-6203cs
dc.identifier.other108004cs
dc.identifier.urihttp://hdl.handle.net/11012/63319
dc.description.abstractBackground and Objectives: Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized in this paper. Methods: Web of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL were searched. Articles were reviewed by two evaluators; quality was assessed by Newcastle-Ottawa scale; meta-analysis was performed including meta-regression and publication bias analysis. Results: Analysis was performed on 114 case control, cohort and cross-sectional studies of 22737 participants. Decreased serum zinc level was found in patients with lung (effect size =21.04), head and neck (effect size =21.43), breast (effect size =20.93), liver (effect size =22.29), stomach (effect size =21.59), and prostate (effect size =21.36) cancers; elevation was not proven in any tumor. More specific zinc patterns are evident at tissue level, showing increase in breast cancer tissue (effect size = 1.80) and decrease in prostatic (effect size =23.90), liver (effect size =28.26), lung (effect size =23.12), and thyroid cancer (effect size =22.84). The rest of the included tumors brought ambiguous results, both in serum and tissue zinc levels across the studies. The association between zinc level and stage or grade of tumor has not been revealed by meta-regression. Conclusion: This study provides evidence on cancer-specific tissue zinc level alteration. Although serum zinc decrease was associated with most tumors mentioned herein, further – prospective - studies are needed.en
dc.description.abstractBackground and Objectives: Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized in this paper. Methods: Web of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL were searched. Articles were reviewed by two evaluators; quality was assessed by Newcastle-Ottawa scale; meta-analysis was performed including meta-regression and publication bias analysis. Results: Analysis was performed on 114 case control, cohort and cross-sectional studies of 22737 participants. Decreased serum zinc level was found in patients with lung (effect size =21.04), head and neck (effect size =21.43), breast (effect size =20.93), liver (effect size =22.29), stomach (effect size =21.59), and prostate (effect size =21.36) cancers; elevation was not proven in any tumor. More specific zinc patterns are evident at tissue level, showing increase in breast cancer tissue (effect size = 1.80) and decrease in prostatic (effect size =23.90), liver (effect size =28.26), lung (effect size =23.12), and thyroid cancer (effect size =22.84). The rest of the included tumors brought ambiguous results, both in serum and tissue zinc levels across the studies. The association between zinc level and stage or grade of tumor has not been revealed by meta-regression. Conclusion: This study provides evidence on cancer-specific tissue zinc level alteration. Although serum zinc decrease was associated with most tumors mentioned herein, further – prospective - studies are needed.cs
dc.formattextcs
dc.format.extent1-11cs
dc.format.mimetypeapplication/pdfcs
dc.language.isoencs
dc.publisherPLOScs
dc.relation.ispartofPLOS ONEcs
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0099790cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectZincen
dc.subjectEpithelial Malignanciesen
dc.subjectMetaAnalysisen
dc.subjectZinc
dc.subjectEpithelial Malignancies
dc.subjectMetaAnalysis
dc.titleSerum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysisen
dc.title.alternativeSerum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysiscs
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
sync.item.dbidVAV-108004en
sync.item.dbtypeVAVen
sync.item.insts2019.08.08 00:57:48en
sync.item.modts2019.08.08 00:16:10en
dc.coverage.issue6cs
dc.coverage.volume9cs
dc.identifier.doi10.1371/journal.pone.0099790cs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1932-6203/cs
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen


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