Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents
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Date
2019-01-02
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Mark
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Mendel University in Brno
Abstract
The current study demonstrates design, preparation and characterization of biocompatible
superparamagnetic iron oxide nanoparticles (SPIONs) coated with three different polymers
polyvinylpyrrolidone (PVP) polyoxyethylene stearate (POES) and chitosan (Chit). Such modified
nanoparticles were loaded with doxorubicin, as model anticancer drug. Resulting complex has an
exceptional stability in physiological conditions. The highest release of complexed Dox was in
endosomal environment in case SPIONs with POES. The cytotoxic effects of the complex were tested
using breast cancer/healthy epithelial cell lines. Use of SPIONs increased the cytotoxicity of doxorubicin
when compared to free doxorubicin and decreased the cytotoxicity in healthy cells. The results
demonstrate that modification of SPIONs could have a potential in nanomedicine as versatile
nanoplatform to enhance efficiency of anticancer therapy.
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Peer-reviewed
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en
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(C) Mendel University in Brno