Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels

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Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids.pdf(1.77 MB)
Date
2020-07-23
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ORCID
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Mark
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Springer Nature
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Abstract
Allyl- and propargyl ethers of umbelliferone are sensitive probes for palladium and platinum, including anticancer compounds cisplatin, carboplatin and oxaliplatin, and effective for direct visualization of protein and DNA complexes with organometallic compounds in polyacrylamide gels allowing easy detection of interactions with analyzed protein or nucleic acid. Both probes can be used for fast evaluation of Pd/Pt binding to nanocarriers relevant in drug targeted therapy or specific clinically relevant target macromolecules.
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Keywords
fluorogenic detection, palladium, platinum, organometallic compounds, polyacrylamide gels
Citation
Scientific Reports. 2020, vol. 10, issue 1, p. 1-10.
https://www.nature.com/articles/s41598-020-69336-w
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Peer-reviewed
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en
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Creative Commons Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
DOI
10.1038/s41598-020-69336-w
URI
http://hdl.handle.net/11012/194807
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Chytré nanonástroje
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