Ratiometric pH-Responsive F-19 Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

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2022-03-14
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American Chemical Society
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Abstract
Hydrazone-based molecular switches serve as eflicient ratiometric pH-sensitive agents that can be tracked with F-19 NMR/MRI and H-1 NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at H-1 and F-19 NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF3 group shifted by 1.8 ppm with F-19 NMR and a hydrazone proton shifted by 2 ppm with H-1 NMR.
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Analytical Chemistry. 2022, vol. 94, issue 8, p. 3427-3431.
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.1c04978
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Peer-reviewed
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en
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Creative Commons Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
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