Modern Micro and Nanoparticle-Based Imaging Techniques

Abstract
The requirements for early diagnostics as well as effective treatment of insidious diseases such as cancer constantly increase the pressure on development of efficient and reliable methods for targeted drug/gene delivery as well as imaging of the treatment success/failure. One of the most recent approaches covering both the drug delivery as well as the imaging aspects is benefitting from the unique properties of nanomaterials. Therefore a new field called nanomedicine is attracting continuously growing attention. Nanoparticles, including fluorescent semiconductor nanocrystals (quantum dots) and magnetic nanoparticles, have proven their excellent properties for in vivo imaging techniques in a number of modalities such as magnetic resonance and fluorescence imaging, respectively. In this article, we review the main properties and applications of nanoparticles in various in vitro imaging techniques, including microscopy and/or laser breakdown spectroscopy and in vivo methods such as magnetic resonance imaging and/or The requirements for early diagnostics as well as effective treatment of insidious diseases such as cancer constantly increase the pressure on development of efficient and reliable methods for targeted drug/gene delivery as well as imaging of the treatment success/failure. One of the most recent approaches covering both the drug delivery as well as the imaging aspects is benefitting from the unique properties of nanomaterials. Therefore a new field called nanomedicine is attracting continuously growing attention. Nanoparticles, including fluorescent semiconductor nanocrystals (quantum dots) and magnetic nanoparticles, have proven their excellent properties for in vivo imaging techniques in a number of modalities such as magnetic resonance and fluorescence imaging, respectively.
Tento článek shrnuje aktuální poznatky o vlastnostech a využití nanočástic pro různé in vitro zobrazovací techniky, včetně mikroskopie a spektroskopie laserem buzeného plazmatu a dále in vivo metod jako jsou magnetické rezonanční zobrazování či fluorescenční zobrazovací techniky. Článek rovněž vyzdvihuje výhody doručování léčiv s použitím nanonosičů jako jsou oxidy železa, zlato, biodegradovatelné polymery, dendrimery, lipidové nosiče včetně lipozomů a micel.
Description
Citation
SENSORS. 2012, vol. 12, issue 11, p. 14792-14820.
http://www.mdpi.com/1424-8220/12/11/14792
Document type
Peer-reviewed
Document version
Published version
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Language of document
en
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Comittee
Date of acceptance
Defence
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Document licence
Creative Commons Attribution 3.0 Unported
http://creativecommons.org/licenses/by/3.0/
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