The methodology for endoluminal irreversible electroporation in porcine models

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dc.contributor.authorGrolich, Tomášcs
dc.contributor.authorAndrašína, Tomášcs
dc.contributor.authorCrha, Michalcs
dc.contributor.authorStehlík, Ladislavcs
dc.contributor.authorRohan, Tomášcs
dc.contributor.authorČervinka, Daliborcs
dc.contributor.authorNovotná, Veronikacs
dc.contributor.authorBernard, Vladancs
dc.contributor.authorSvobodová, Ivacs
dc.contributor.authorVálek, Vlastimilcs
dc.coverage.issue2cs
dc.coverage.volume88cs
dc.date.accessioned2020-08-04T11:01:16Z
dc.date.available2020-08-04T11:01:16Z
dc.date.issued2019-04-23cs
dc.description.abstractThe aim of this study was to describe the methodology of the surgical technique for endoluminal irreversible electroporation in the biliary tract performed within the perihilar region in porcine models. Endoluminal irreversible electroporation of the common bile duct was performed on eight porcine models using an endoluminal device inserted during laparotomy. The endoluminal device consisted of three electrodes 1 cm in length, attached at 120 degrees around the balloon catheter. The procedure was conducted with the following parameters: number of pulses 90, voltage of 1500 V between each couple of electrodes. Cross sectional imaging and histopathological assessment were employed for evaluations of the ablation zone. Models were sacrificed 24 h and 96 h after ablation. The treatment was successful in all porcine models. All animals survived the defined study period. Peri-ablation oedema within the hepatoduodenal ligament and adjacent liver tissue could be measured on post-procedural MRI or CT. Perforation in the site of ablation developed in one model. Histopathological examination showed heavy regressive changes of the ablated tissue. The elastic membranes of the adjacent portal vein were preserved in all models. In our experience, this novel endoluminal modality used within the perihilar region in porcine models is a feasible and well predictable procedure. Further studies should explore the optimal protocol of catheter-based ablation to limit complications.en
dc.formattextcs
dc.format.extent201-205cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACTA VETERINARIA BRNO. 2019, vol. 88, issue 2, p. 201-205.en
dc.identifier.doi10.2754/avb201988020201cs
dc.identifier.issn1801-7576cs
dc.identifier.other157795cs
dc.identifier.urihttp://hdl.handle.net/11012/184647
dc.language.isoencs
dc.publisherActa Veterinaria Brnocs
dc.relation.ispartofACTA VETERINARIA BRNOcs
dc.relation.urihttps://actavet.vfu.cz/88/2/0201/cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1801-7576/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectBiliary ablationen
dc.subjectmagnetic resonance imagingen
dc.subjectintraductal ablationen
dc.subjectexperimental studyen
dc.titleThe methodology for endoluminal irreversible electroporation in porcine modelsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-157795en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:01:16en
sync.item.modts2020.08.04 12:28:24en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav výkonové elektrotechniky a elektronikycs
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