Drug Release Kinetics of Electrospun PHB Meshes

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dc.contributor.authorKundrát, Vojtěchcs
dc.contributor.authorČerneková, Nicolecs
dc.contributor.authorKovalčík, Adriánacs
dc.contributor.authorEnev, Vojtěchcs
dc.contributor.authorMárová, Ivanacs
dc.coverage.issue12cs
dc.coverage.volume12cs
dc.date.accessioned2020-08-04T10:59:49Z
dc.date.available2020-08-04T10:59:49Z
dc.date.issued2019-06-14cs
dc.description.abstractMicrobial poly(3-hydroxybutyrate) (PHB) has several advantages including its biocompatibility and ability to degrade in vivo and in vitro without toxic substances. This paper investigates the feasibility of electrospun PHB meshes serving as drug delivery systems. The morphology of the electrospun samples was modified by varying the concentration of PHB in solution and the solvent composition. Scanning electron microscopy of the electrospun PHB scaffolds revealed the formation of different morphologies including porous, filamentous/beaded and fiber structures. Levofloxacin was used as the model drug for incorporation into PHB electrospun meshes. The entrapment efficiency was found to be dependent on the viscosity of the PHB solution used for electrospinning and ranged from 14.4–81.8%. The incorporation of levofloxacin in electrospun meshes was confirmed by Fourier-transform infrared spectroscopy and UV-VIS spectroscopy. The effect of the morphology of the electrospun meshes on the levofloxacin release profile was screened in vitro in phosphate-buffered saline solution. Depending upon the morphology, the electrospun meshes released about 14–20% of levofloxacin during the first 24 h. The percentage of drug released after 13 days increased up to 32.4% and was similar for all tested morphologies. The antimicrobial efficiency of all tested samples independent of the morphology, was confirmed by agar diffusion testing.en
dc.formattextcs
dc.format.extent1-13cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMaterials . 2019, vol. 12, issue 12, p. 1-13.en
dc.identifier.doi10.3390/ma12121924cs
dc.identifier.issn1996-1944cs
dc.identifier.other157318cs
dc.identifier.urihttp://hdl.handle.net/11012/181097
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofMaterialscs
dc.relation.urihttps://www.mdpi.com/1996-1944/12/12/1924cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1996-1944/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectbiomaterialsen
dc.subjectelectrospinningen
dc.subjectdrug release kineticsen
dc.subjectlevofloxacinen
dc.subjectmorphologyen
dc.subjectpoly(3-hydroxybutyrate)en
dc.subjectscaffoldsen
dc.titleDrug Release Kinetics of Electrospun PHB Meshesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-157318en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 12:59:49en
sync.item.modts2020.08.04 12:42:44en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie potravin a biotechnologiícs
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav fyzikální a spotřební chemiecs
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