Effect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agents

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dc.contributor.authorBuchtelová, Hanacs
dc.contributor.authorŠkubalová, Zuzanacs
dc.contributor.authorKudr, Jiřícs
dc.contributor.authorStrmiska, Vladislavcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorHeger, Zbyněkcs
dc.date.accessioned2019-06-20T06:10:43Z
dc.date.available2019-06-20T06:10:43Z
dc.date.issued2019-01-02cs
dc.description.abstractThe current study demonstrates design, preparation and characterization of biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) coated with three different polymers polyvinylpyrrolidone (PVP) polyoxyethylene stearate (POES) and chitosan (Chit). Such modified nanoparticles were loaded with doxorubicin, as model anticancer drug. Resulting complex has an exceptional stability in physiological conditions. The highest release of complexed Dox was in endosomal environment in case SPIONs with POES. The cytotoxic effects of the complex were tested using breast cancer/healthy epithelial cell lines. Use of SPIONs increased the cytotoxicity of doxorubicin when compared to free doxorubicin and decreased the cytotoxicity in healthy cells. The results demonstrate that modification of SPIONs could have a potential in nanomedicine as versatile nanoplatform to enhance efficiency of anticancer therapy.en
dc.formattextcs
dc.format.extent489-494cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMendelNet 2018. 2019, p. 489-494.en
dc.identifier.isbn978-80-7509-597-8cs
dc.identifier.other156233cs
dc.identifier.urihttp://hdl.handle.net/11012/178380
dc.language.isoencs
dc.publisherMendel University in Brnocs
dc.relation.ispartofMendelNet 2018cs
dc.relation.urihttps://mendelnet.cz/artkey/mnt-201801-0102_Effect-of-surfactants-and-polymers-on-stability-of-superparamagnetic-nanoparticles-and-on-immobilization-and-re.php?back=/magno/mnt/2018/mn1.php?secid=4cs
dc.rights(C) Mendel University in Brnocs
dc.rights.accessopenAccesscs
dc.subjectbiocompatibilityen
dc.subjectSPIONen
dc.subjectnanomedicineen
dc.subjectcytotoxicityen
dc.titleEffect of surfactants and polymers on stability of superparamagnetic nanoparticles and on immobilization and release of antitumor agentsen
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-156233en
sync.item.dbtypeVAVen
sync.item.insts2020.03.31 09:58:23en
sync.item.modts2020.03.31 07:38:12en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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